This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations.
Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors.
The most encyclopedic book on the pancreas providing outstanding and clear guidance for the practicing clinician
Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management
Completely updated with brand new chapters
Over 500 downloadable illustrations
An editor and author team of high international repute who present global best-practice
The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
Contents
Contributors,
Preface to the Third Edition,
List of abbreviations,
Section 1: Anatomy of the Pancreas
1. Development of the pancreas and related structures
Brian Lewis, Junhao Mao
2. Anatomy and the fine structure of the pancreas
Daniel S. Longnecker, Fred Gorelick, Elizabeth D. Thompson
3. Congenital and inherited anomalies
Martin Zenker, Markus M. Lerch
Section 2: Physiology and Pathophysiology of Pancreatic Functions
4. Physiology of acinus cell secretion
Ole H. Petersen
5. Physiology of duct cell secretion
Mei Zeng, Laura Vachel, Shmuel Muallem
6. Pathophysiology of experimental pancreatitis
Vikas Dudeja, Rajinder Dawra, Ashok Saluja
7. Physiology and pathophysiology of function of sphincter of Oddi
Savio George Barreto, James Toouli
8. Neurohormonal and hormonal control of pancreatic secretion
Chung Owyang
9. Regulation of pancreatic protein synthesis and growth
Maria Dolors Sans, John A. Williams
10. Fibrogenesis of the pancreas: The role of stellate cells
Minoti V. Apte, Romano C. Pirola, Jeremy S. Wilson
11. Fibrogenesis of the pancreas: The role of macrophages
Aida Habtezion
12. Insulo-acinar relationship
Keiko Shiratori, Kyoko Shimizu
Section 3: Acute Pancreatitis
13. Epidemiology and etiology of alcohol-induced pancreatitis
Jeremy Wilson, Romano Pirola, Minoti Apte
14. Etiology and epidemiology of biliary acute pancreatitis
Michael G. T. Raraty, Andrea Sheel, John Neoptolemos
15. Genetic factors in acute pancreatitis
Zachary Zator, Georgios I. Papachristou
16. The role of the intestine and the mesenteric lymph in the development of SIRS and MODS in severe acute pancreatitis
Alistair B. J. Escott, Anthony R. J. Phillips, John A. Windsor
17. Neuroinflammation in acute pancreatitis
Jami L. Saloman, Kathryn M. Albers, Brian M. Davis
18. Molecular biochemical and metabolic abnormalities of acute pancreatitis
Julia Mayerle, F. Ulrich Weiss, Walter Halangk, Markus M. Lerch
19. Histopathology of acute pancreatitis
Günter Klöppel
20. Clinical classification systems of acute pancreatitis
John A. Windsor, M. S. Petrov
21. Clinical assessment and biochemical markers to objectify severity and prognosis
Bettina M. Rau, Guido Alsfasser
22. Acute pancreatitis associated with congenital anomalies
Christopher R. Schlieve, Andrew L. Warshaw, Tracy C. Grikscheit
23. Acute pancreatitis in children
Mark E. Lowe, Véronique D. Morinville
24. Acute pancreatitis associated with metabolic, infections and drug-related diseases
Ali A. Aghdassi, Markus M. Lerch
25. Radiologic diagnosis and staging of severe acute pancreatitis
Yoshihisa Tsuji
Clinical course and medical treatment of acute pancreatitis (26 29)
26. Conservative therapy of acute pancreatitis: Volume substitution and enteral and parenteral nutrition
Timothy B. Gardner
27. ICU treatment of severe acute pancreatitis
Scott R. Gunn, David C. Whitcomb
28. The use of antibiotics in severe acute pancreatitis: Indications and limitations
Rainer Isenmann, Mathias Wittau
29. Indication for interventional and surgical treatment of necrotizing pancreatitis
Thomas E. Clancy
30. Management of infected pancreatic necroses: An endoscopic approach
Eduardo Rodrigues-Pinto, Todd H. Baron
31. Minimal-invasive debridement and lavage of necrotizing pancreatitis
Rebecca Saunders, Michael Raraty, Chris Halloran, John Neoptolemos
32. Open surgical debridement of necrotizing pancreatitis
Lutz Schneider, Markus W. Büchler
33. Endoscopic treatment of biliary acute pancreatitis
Ichiro Yasuda, Shinpei Doi, Masatoshi Mabuchi
34. Strategies of management of pseudo cysts and walled-off necroses after acute pancreatitis: Interventional endoscopic approach
Georg Beyer, Julia Mayerle, Markus M. Lerch
35. Surgical treatment of pseudo cysts and walled-off necroses after acute pancreatitis
Naohiro Sata, Masaru Koizumi, Alan K. Lefor
36. Management of fluid collection in acute pancreatitis
Felix Lämmerhirt, Frank Ulrich Weiss, Markus M. Lerch
37. Management of pancreatic fistula in acute pancreatitis
Jörg Kaiser, Thilo Hackert, Markus W. Büchler
38. Long-term outcome after acute pancreatitis
Christin Tjaden, Thilo Hackert
Section 4: Chronic Pancreatitis
39. Molecular understanding of chronic pancreatitis
John F. Eisses, Sohail Z. Husain
40. Epidemiology and pathophysiology of alcoholic chronic pancreatitis
Atsushi Masamune, Tooru Shimosegawa
41. Pain mechanisms in chronic pancreatitis
Pierluigi di Sebastiano, Tommaso Grottola, Francesco F. di Mola
42. Natural history of recurrent acute and chronic pancreatitis
Rohit Das, Dhiraj Yadav
43. Chronic pancreatitis with inflammatory mass in the pancreatic head
Ulrich F. Wellner, Tobias Keck
44. Early stage chronic pancreatitis
Tetsuhide Ito, Masayuki Hijioka, Tooru Shimosegawa
45. Hereditary chronic pancreatitis: Molecular pattern, clinical consequences, management principles
Celeste Shelton, David C. Whitcomb
46. Epidemiology and pathophysiology of tropical chronic pancreatitis
Shailesh V. Shrikhande, Savio G. Barreto
47. Cystic fibrosis (CFTR)-associated pancreatic disease
Chee Y. Ooi, Aliye Uc
48. Clinical and laboratory diagnosis of chronic pancreatitis
Julia Mayerle, Peter Simon, Markus M. Lerch
49. Evidence of contrast enhanced CT and MRI/MRCP
J. Enrique Domínguez-Muñoz, Roberto García-Figueiras, Julio Iglesias-García
50. Chronic pancreatitis: Risk factors in cancer
Albert B. Lowenfels, Patrick Maisonneuve
51. Pain management of chronic pancreatitis
Kai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, Jakob Robert Izbicki
52. Medical treatment of chronic pancreatitis: Pancreatic digestive enzymes: lipases, proteases
Mark E. Lowe
53. Nutritional support of chronic pancreatitis
Sinead N. Duggan, Stephen J. O'Keefe
54. Medical treatment of chronic pancreatitis: Antioxidants
Chris E. Forsmark
Strategies for surgical treatment of chronic pancreatitis (55 60)
55. Evidence of endoscopic and interventional treatment of chronic pancreatitis and pseudocysts
Jörg Schirra, Markus M. Lerch, Julia Mayerle
56. Indications and goals of surgical treatment
Ryan T. Groeschl, Michael B. Farnell
57. Pancreatic duct drainage procedure
D. Bausch, Tobias Keck
58. Duodenum preserving pancreatic head resection
Hans G. Beger, Bertram Poch, Yang Yinmo, Waldemar Uhl
59. Major pancreatic resection
May C. Tee, Michael B. Farnell
60. Laparoscopic surgery
Vernissia Tam, Melissa Hogg, Amer Zureikat
61. Chronic pancreatitis: Late outcome after medical and surgical treatment
Volker A falg, Norbert Hüser, Helmut Friess
62. Management of pancreatic diabetes secondary to chronic pancreatitis
Keiko Shiratori
Section 5: Autoimmune Pancreatitis
63. Epidemiology of autoimmune pancreatitis
Terumi Kamisawa, Tooru Shimosegawa
64. Pathogenesis of autoimmune pancreatitis
Yoh Zen
65. Histology of autoimmune pancreatitis
Rajib Gupta, Vikram Deshpande
66. Clinical manifestation of type 1 autoimmune pancreatitis
Tooru Shimosegawa, Morihisa Hirota, Atsushi Kanno
67. Clinical manifestation of type 2 autoimmune pancreatitis
Emma L. Culver, George Webster
68. Laboratory diagnosis of autoimmune pancreatitis
J.-Matthias Löhr, Pia Maier, Stephan L. Haas
69. What is the evidence measuring immune markers
Shigeyuki Kawa
70. Imaging diagnosis of autoimmune pancreatitis
Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, Makoto Takaoka
71. Medical treatment of autoimmune pancreatitis
Shounak Majumder, Suresh T. Chari
72. Long-term outcomes after treatment of autoimmune pancreatitis
Luca Frulloni, Nicolò de Pretis
Section 6: Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas
73. Epidemiology of cystic neoplasm of the pancreas
Saurabh Mukewar, Suresh Chari
74. Histologic classification and staging of cystic neoplasm
Noriyoshi Fukushima, Giuseppe Zamboni
75. Molecular mechanisms of cystic neoplasm
Nickolas Papadopoulos, Ralph H. Hruban
76. Clinical presentation of cystic neoplasm
Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao
77. Evaluation of cystic lesions using EUS, MRT, and CT
Anne Marie Lennon, Hiroyuki Maguchi
78. Cytologic evaluation of cystic neoplasm
Martha Bishop Pitman
79. Natural history of cystic neoplasm: IPMN, MCN, SCN, and SPN
Anna-Katharina Stadler, Thilo Hackert, Stefan Fritz, Markus W. Büchler
80. Surveillance or surgical treatment in asymptomatic cystic neoplasm
Klaus Sahora, Carlos Fernández-del Castillo
Local and Standard Surgical Treatment of Cystic Neoplasms (81 85)
81. Duodenum-preserving partial or total pancreatic head resection
Hans G. Beger,Bertram Poch
82. Pancreatic middle segment resection of cystic neoplasms
Calogero Iacono
83. Enucleation of cystic neoplasms: Indication and limitation
Rosalie A. Carr, C. Max Schmidt, Henry A. Pitt
84. Standard surgical management of IPMN, MCN, SPN, and SCN lesions: An open approach
Miral Sadaria Grandhi, Barish H. Edil, Richard D. Schulick
85. Surgical treatment of cystic neoplasm: Laparoscopic approach
Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, Thilo Hackert
86. Management of recurrence of cystic neoplasm
Zhi Ven Fong, Christopher L. Wolfgang, Keith D. Lillemoe
87. Long-term outcome after observation and surgical treatment of cystic neoplasm. What is the evidence?
Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi
Section 7: Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer
88. Epidemiology of pancreatic cancer
Evelina Mocci, Alison P. Klein
89. Smoking, a risk for pancreatic cancer: Experimental and clinical data
Uwe A. Wittel, Bradley R. Hall , Surinder K. Batra
90. Molecular understanding of development of ductal pancreatic cancer
Laura D. Wood, Ralph H. Hruban
91. Familial pancreatic cancer
Alison P. Klein
92. Pathology of exocrine pancreatic tumors
Meredith E. Pittman, Ralph H. Hruban
93. Pancreatic cancer: Precancerous lesions
Michaël Noë, Lodewijk A. A. Brosens, Johan Offerhaus
94. Clinical history and risk factors of pancreatic cancer
Norbert Hüser, Volker A falg, Helmut Friess
95. Pancreatic cancer within uncinate process: Radiologic and clinical characteristics
Sebastian Holländer, Dieter Birk
96. The role of EUS for diagnosis and differential diagnosis of neoplastic lesions
Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao
97. Radiological diagnosis of pancreatic cancer: CT, MRI
Siva P. Raman, Elliot K. Fishman
98. Screening of hereditary pancreatic cancer
Michael Goggins
99. The role of PET in diagnosis of pancreatic cancer and cancer recurrence
Norbert Hüser, Volker A falg, Isabel Rauscher, Helmut Friess
100. Tumor markers in pancreatic malignancies
Shin Hamada, Atsushi Masamune, Tooru Shimosegawa
101. The role of laparoscopy and peritoneal cytology in the management of pancreatic cancer
Kyoichi Takaori, Shinji Uemoto
102. Clinical assessment and staging of advanced pancreatic cancer
Jennifer LaFemina, Ann K. Friedrich, Giles F. Whalen
Surgical Treatment of Pancreatic Cancer (103 110)
103. Pancreatic cancer: Indications for resection
Akimasa Nakao
104. Pancreaticoduodenectomy for pancreatic cancer, short and long-term outcome after Kausch-Whipple and pylorus-preserving resection
Jin He, John L. Cameron
105. Left pancreatectomy for body and tail cancer
Georgios Gemenetzis, Christopher L. Wolfgang
106. Total pancreatectomy: Indication and limitations
Seiko Hirono, Hiroki Yamaue
107. Laparoscopic and robotic resection for pancreatic cancer
D. Magge, Herbert J. Zeh, Melissa E. Hogg
108. Extended radical surgery for pancreatic cancer
Thilo Hackert, Alexis Ulrich, Markus W. Büchler
109. Palliative pancreaticoduodenectomy: Benefits and limitations
Christoph W. Michalski, Max Heckler, Mert Erkan, Markus W. Büchler
110. Bypass surgery for advanced pancreatic cancer
Jürgen Weitz, Thomas Pausch, Christoph W. Michalski, Thilo Hackert
111. Endoscopic and interventional palliation of pancreatic cancer
Takao Itoi
112. Neoadjuvant treatment of pancreatic cancer: Downstaging results
Robert A. Wolff, Gauri Varadhachary
113. Adjuvant chemotherapy in pancreatic cancer: First line and second line treatment: Benefits of survival
Robert P. Jones, Paula Ghaneh, John P. Neoptolemos
114. Immunotherapy for pancreatic cancer
Adrian G. Murphy, Elizabeth M. Jaffee, Lei Zheng
115. Targeted therapies for pancreatic cancer
Vincent Bernard, Anirban Maitra
116. Palliative chemotherapy for advanced pancreatic cancer: Treatment modalities, side effects and benefits of survival
Olusola O. Faluyi, Madhuchanda Chatterjee, Daniel H. Palmer
117. Management of pain in pancreatic cancer
Michael Erdek
118. Role of radio and proton beam therapy for pancreatic cancer
Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, Joseph M. Herman
119. Management of cancer recurrence
Oliver Strobel, Markus W. Büchler
120. Survival and late morbidity after resection of pancreatic cancer
Avinoam Nevler, Charles J. Yeo, Jordan M. Winter
Section 8: Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas
121. Epidemiology and classification of neuroendocrine tumors of the pancreas
J. J. Mukherjee, Kok-Onn Lee, Gregory Kaltsas
122. Pathology of neuroendocrine tumors
Atsuko Kasajima, Hironobu Sasano
123. Molecular genetic of neuroendocrine tumors
Nickolas Papadopoulos, Ralph H. Hruban
124. Clinical manifestation of endocrine tumors of the pancreas
Ken Kawabe, Tetsuhide Ito
125. Evidence of hormonal, laboratory, biochemistric and instrumental diagnostics of neuroendocrine tumors of the pancreas
Kok-Onn Lee, Gregory Kaltsas, J. J. Mukherjee
126. Pancreatic neuroendocrine tumors in multiple neoplasia syndromes
A. Rinke, T. M. Gress
127. Non-functioning neuroendocrine tumors: Diagnosis and management principles
Takao Ohtsuka, Hideyo Kimura, Masafumi Nakamura
128. Medical and nucleotid treatment of neuroendocrine tumors of the pancreas
Gregory Kaltsas, J. J. Mukherjee, Kok-Onn Lee
129. Interventional radiology treatment of neuroendocrine tumors
Takao Ohtsuka, Hideyo Kimura, Masafumi Nakamura
Surgical Treatment of Endocrine Tumors of the Pancreas (130 136)
130. Enucleation of neuroendocrine tumors
Henning Dralle, Phuong Nguyen Thanh, Andreas Machens
131. Middle segment pancreatectomy and duodenum-preserving pancreatic head resection for neurendocrine tumors
Hans G. Beger, Wataru Kimura
132. Major oncologic resection for neuroendocrine tumors
Henning Dralle, Phuong Nguyen Thanh, Andreas Machens
133. Management of insulinoma
Keijiro Ueda, Linkaku Lee, Tetsuhide Ito
134. Gastrinoma: Evidence of medical and surgical treatment
Ryuichiro Doi
135. Rare neuroendocrine tumors of the pancreas: Management and evidence of surgical treatment
Ryuichiro Doi
136. Treatment of neuroendocrine tumors of the pancreas and biliary tract
Andrea Frilling, Ashley K. Clift, Vito Cicinnati
137. Long-term outcome after treatment of endocrine tumors
Andreas Machens, Henning Dralle
Section 9: Periampullary Tumors and others than Pancreatic Cancer
138. Periampullary tumors: Clinical presentation and diagnostic strategy
Amanda Cooper, Keith D. Lillemoe
139. Histology and genetics of cancer of the papilla, distal common bile duct and duodenum
Yue Xue, Michelle D. Reid, Volkan Adsay
140. Adenoma and adenocarcinoma of the Ampulla of Vater: Diagnosis and management
Omer Basar, William R. Brugge
141. Endoscopic treatment of adenomas of the Ampulla of Vater: Techniques, results, benefits and limitations
Natsuyo Yamamoto, Hiroyuki Isayama, Kazuhiko Koike
142. Surgical treatment of adenoma and cancer of papilla Vater
Hans G. Beger, Bertram Poch, Bettina M. Rau
143. Surgical treatment of duodenal cancer
Fuyuhiko Motoi, Michiaki Unno
144. Surgical treatment of distal cholangiocarcinoma
Yukihiro Yokoyama, Tomoki Ebata, Masato Nagino
145. Adjuvant and palliative chemotherapy of periampullary cancer: First line treatment and outcome
Eyas Mohamed, Paula Ghaneh, John Neoptolemos
146. Long-term survival after resection of periampullary cancer
Masayuki Ohtsuka, Masaru Miyazaki
Section 10: Transplantation of the Pancreas
147. Transplantation of pancreatic islets
Bernhard J. Hering, Melena D. Bellin
148. Transplantation of the pancreas
Hans W. Sollinger, Dixon B. Kaufman
Index, xxx