This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of pediatric neoplasms, including recent molecular advances in the field, this volume incorporates the most up-to-date scientific and technical knowledge to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Pediatric Neoplasms is a visually stunning, one-stop resource for every practicing pathologist, resident, student, or fellow as an ideal day-to-day reference or as a reliable training resource.


PART I: SKIN

SECTION 1: BENIGN

4 Blue Nevus

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

8 Epidermal Nevus

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

12 Epidermodysplasia Verruciformis

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

14 Langerhans Cell Histiocytosis

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

18 Melanocytic Nevus

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

24 Organoid Nevus

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

26 Pilomatricoma

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

30 Pyogenic Granuloma

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

32 Spitz Nevus

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

36 Syringoma

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

38 Trichilemmoma

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

42 Trichoepithelioma

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA

46 Verruca Vulgaris

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA



SECTION 2: BORDERLINE

50 Dysplastic Nevus

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA



SECTION 3: MALIGNANT PRIMARY

54 Malignant Melanoma

Christopher Lum, MD, Emily Leibovitch, BA, and Amity Tran, BA



PART II: SOFT TISSUE

SECTION 1: BENIGN

64 Calcifying Aponeurotic Fibroma

Jeremy C. Wallentine, MD and Angelica R. Putnam, MD

66 Calcifying Fibrous Tumor

Jeremy C. Wallentine, MD and Angelica R. Putnam, MD

68 Cellular Neurothekeoma

Alexandros D. Polydorides, MD, PhD and Angelica R. Putnam, MD

72 Congenital Hemangioma

Kandi Stallings-Archer, MD

76 Diffuse Lipomatosis

Angelica R. Putnam, MD

78 Fetal Rhabdomyoma

Cyril Fisher, MD, DSc, FRCPath

82 Fibrodysplasia Ossificans Progressiva

Angelica R. Putnam, MD

84 Fibrolipomatous Hamartoma of Nerve

Angelica R. Putnam, MD and Cyril Fisher, MD, DSc, FRCPath

86 Fibromatosis Colli

Angelica R. Putnam, MD and Cyril Fisher, MD, DSc, FRCPath

88 Fibrous Hamartoma of Infancy

Jessica M. Comstock, MD and Angelica R. Putnam, MD

90 Fibrous Histiocytoma

Karen S. Thompson, MD

94 Fibrous Umbilical Polyp

Larissa V. Furtado, MD

96 Gardner Fibroma

Larissa V. Furtado, MD

98 Giant Cell Fibroblastoma/Dermatofibrosarcoma Protuberans

Karen S. Thompson, MD and Angelica R. Putnam, MD

104 Glomuvenous Malformation

Angelica R. Putnam, MD and Jeremy C. Wallentine, MD

106 Hemangioma of Infancy

Jeremy C. Wallentine, MD and Angelica R. Putnam, MD

110 Heterotopic Neuroglial Tissue

Alexandros D. Polydorides, MD, PhD

112 Inclusion Body Fibromatosis

Elizabeth A. Montgomery, MD

116 Infantile Fibromatosis

Larissa V. Furtado, MD and Angelica R. Putnam, MD

118 Infantile Hemangiopericytoma

Karen S. Thompson, MD

120 Infantile/Juvenile Hyaline Fibromatosis

Elizabeth A. Montgomery, MD

122 Inflammatory Myofibroblastic Tumor

Karen S. Thompson, MD and Angelica R. Putnam, MD

128 Intramuscular Fast-Flow Anomaly

Angelica R. Putnam, MD

132 Juvenile Xanthogranuloma

Jessica M. Comstock, MD

134 Kaposiform Lymphangiomatosis

Angelica R. Putnam, MD

138 Lipoblastoma

Jessica M. Comstock, MD and Angelica R. Putnam, MD

140 Lipofibromatosis

Angelica R. Putnam, MD

144 Melanotic Neuroectodermal Tumor of Infancy

Jeremy C. Wallentine, MD

146 Myofibroma and Myofibromatosis

Angelica R. Putnam, MD and Elizabeth A. Montgomery, MD

150 Myopericytoma

Karen S. Thompson, MD

152 Myositis Ossificans

Angelica R. Putnam, MD

154 Neurofibroma

Alexandros D. Polydorides, MD, PhD

160 Nodular Fasciitis

Jeremy C. Wallentine, MD and Angelica R. Putnam, MD

164 Proliferative Fasciitis/Myositis

Jeremy C. Wallentine, MD and Angelica R. Putnam, MD

166 Rhabdomyomatous Mesenchymal Hamartoma

Angelica R. Putnam, MD

168 Schwannoma

Jessica M. Comstock, MD and Angelica R. Putnam, MD

172 Spindle Cell Hemangioma

Jeremy C. Wallentine, MD

174 Tufted Angioma

Jeremy C. Wallentine, MD



SECTION 2: BORDERLINE

178 Desmoid-Type Fibromatosis

Karen S. Thompson, MD

182 Kaposiform Hemangioendothelioma

Jeremy C. Wallentine, MD

186 Receptor Tyrosine Kinase Rearranged Spindle Cell Tumor

Angelica R. Putnam, MDSECTION 3: MALIGNANT PRIMARY

192 Alveolar Soft Part Sarcoma

Karen S. Thompson, MD

194 Clear Cell Sarcoma (Melanoma of Soft Parts)

Jerad M. Gardner, MD

198 Desmoplastic Small Round Cell Tumor

Angelica R. Putnam, MD

204 Infantile Fibrosarcoma

Karen S. Thompson, MD

208 Malignant Peripheral Nerve Sheath Tumor

Karen S. Thompson, MD

214 Rhabdomyosarcoma

Karen S. Thompson, MD

224 Synovial Sarcoma

Angelica R. Putnam, MD

230 Undifferentiated Round Cell Tumors of Soft Tissue

Karen S. Thompson, MD



PART III: BONE AND JOINT



SECTION 1: BENIGN

234 Adamantinoma

Jessica M. Comstock, MD

236 Aneurysmal Bone Cyst

Jessica M. Comstock, MD

240 Chondroblastoma

Sarah Culkin Mengshol, MD

244 Chondromyxoid Fibroma

Kelley E. Capocelli, MD and Karen S. Thompson, MD

250 Enchondroma

Jessica M. Comstock, MD

252 Fibrous Dysplasia

Sarah Culkin Mengshol, MD

254 Giant Cell Tumor

Jessica M. Comstock, MD and Karen S. Thompson, MD

258 Nonossifying Fibroma

Sarah Culkin Mengshol, MD

260 Osteoblastoma

Kelley E. Capocelli, MD

266 Osteochondroma

Sarah Culkin Mengshol, MD

270 Osteofibrous Dysplasia

Karen S. Thompson, MD

272 Osteoid Osteoma

Kelley E. Capocelli, MD

278 Osteoma

Angelica R. Putnam, MD and Andrew E. Rosenberg, MD

282 Simple Bone Cyst

Jessica M. Comstock, MD and Karen S. Thompson, MD

286 Synovial Lipomatosis (Hoffa Disease)

Jeremy C. Wallentine, MD

288 Tenosynovial Giant Cell Tumor

Karen S. Thompson, MD



SECTION 2: MALIGNANT PRIMARY

296 Chondrosarcoma

Jessica M. Comstock, MD and Karen S. Thompson, MD

300 Chordoma

Jessica M. Comstock, MD and Karen S. Thompson, MD

302 Ewing Sarcoma

Angelica R. Putnam, MD

308 Osteosarcoma

Angelica R. Putnam, MD



PART IV: BREAST



SECTION 1: BENIGN

322 Fibroadenoma

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

326 Fibrocystic Change

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

330 Gynecomastia

Jeremy C. Wallentine, MD

332 Juvenile Fibroadenoma

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

334 Juvenile Hypertrophy

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

336 Juvenile Papillomatosis

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

338 Pseudoangiomatous Stromal Hyperplasia

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

342 Tubular Adenoma

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD



SECTION 2: BORDERLINE

346 Phyllodes Tumor

Jeremy C. Wallentine, MD and Jeffrey L. Killeen, MD

SECTION 3: MALIGNANT PRIMARY

352 Secretory Carcinoma

David G. Hicks, MD and Jeffrey L. Killeen, MD



PART V: CENTRAL NERVOUS SYSTEM



SECTION 1: BENIGN

358 Craniopharyngioma

Alexandros D. Polydorides, MD, PhD

364 Ganglion Cell Tumors

Alexandros D. Polydorides, MD, PhD

372 Meningioangiomatosis

Alexandros D. Polydorides, MD, PhD

376 Pilocytic Astrocytoma

Alexandros D. Polydorides, MD, PhD

382 Subependymal Giant Cell Astrocytoma

Alexandros D. Polydorides, MD, PhD

SECTION 2: MALIGNANT PRIMARY

390 Anaplastic Astrocytoma

Alexandros D. Polydorides, MD, PhD

392 Astroblastoma

Peter C. Burger, MD and B. K. Kleinschmidt-DeMasters, MD

398 Atypical Teratoid/Rhabdoid Tumor

Alexandros D. Polydorides, MD, PhD

404 Central Nervous System Embryonal Tumors

Alexandros D. Polydorides, MD, PhD and Fausto J. Rodríguez, MD

416 Choroid Plexus Tumors

Alexandros D. Polydorides, MD, PhD

424 Diffuse Astrocytoma (Low Grade)

Alexandros D. Polydorides, MD, PhD

430 Ependymoma

Alexandros D. Polydorides, MD, PhD

438 Glioblastoma

Alexandros D. Polydorides, MD, PhD

448 Medulloblastoma

Alexandros D. Polydorides, MD, PhD

458 Oligodendroglioma

Alexandros D. Polydorides, MD, PhD

466 Pineal Parenchymal Tumors

Alexandros D. Polydorides, MD, PhD

474 Pleomorphic Xanthoastrocytoma

Alexandros D. Polydorides, MD, PhD



PART VI: ENDOCRINE

480 Adrenal Cortical Adenoma

Kelley E. Capocelli, MD

488 Adrenal Cortical Neoplasms

Kelley E. Capocelli, MD

498 Follicular Adenoma

Vania Nosé, MD, PhD

504 Follicular Thyroid Neoplasms

Jeremy C. Wallentine, MD and Vania Nosé, MD, PhD

512 Ganglioneuroma

Jessica M. Comstock, MD

514 Medullary Thyroid Carcinoma

Vania Nosé, MD, PhD

520 Neuroblastic Tumors

Jessica M. Comstock, MD and Karen S. Thompson, MD

530 Papillary Thyroid Carcinoma

Angelica R. Putnam, MD



PART VII: HEAD AND NECK



SECTION 1: BENIGN

540 Pleomorphic Adenoma

Larissa V. Furtado, MD and Brenda L. Nelson, DDS, MS

548 Salivary Gland Anlage Tumor

Angelica R. Putnam, MD

550 Sialoblastoma

Angelica R. Putnam, MD

SECTION 2: MALIGNANT PRIMARY

554 Mucoepidermoid Carcinoma

Larissa V. Furtado, MD and Brenda L. Nelson, DDS, MS

562 Retinoblastoma

Jessica M. Comstock, MD



PART VIII: THORACIC



SECTION 1: BENIGN

568 Cardiac Fibroma

Aliya N. Husain, MD

570 Cardiac Rhabdomyoma

Aliya N. Husain, MD

572 Cystic Teratoma of Heart

Aliya N. Husain, MD

574 Histiocytoid Cardiomyopathy

Bahig M. Shehata, MD

578 Laryngotracheal Papillomatosis

Aliya N. Husain, MD

SECTION 2: MALIGNANT PRIMARY

582 Pleuropulmonary Blastoma

Aliya N. Husain, MD and Angelica R. Putnam, MD

586 Thymoma

Saul Suster, MD



PART IX: ALIMENTARY CANAL



SECTION 1: BENIGN

604 Cronkite-Canada Syndrome

Scott R. Owens, MD

606 Familial Adenomatous Polyposis

Scott R. Owens, MD

610 Gingival Granular Cell Tumor of Newborn

Larissa V. Furtado, MD

614 Hamartomatous Polyps, Including Juvenile Polyps

618 Inflammatory Polyps

Scott R. Owens, MD

622 Juvenile Polyps

Scott R. Owens, MD

624 Neuroendocrine Tumors

Larissa V. Furtado, MD and Angelica R. Putnam, MD

628 Peutz-Jeghers Polyps

Scott R. Owens, MD



SECTION 2: MALIGNANT PRIMARY

634 Gastrointestinal Stromal Tumor

Angelica R. Putnam, MD and Elizabeth A. Montgomery, MD



PART X: LIVER/PANCREAS



SECTION 1: BENIGN

640 Focal Nodular Hyperplasia

Larissa V. Furtado, MD and Angelica R. Putnam, MD

642 Hepatic Adenomas

Matthew M. Yeh, MD, PhD

646 Hepatic Hemangiomas

Angelica R. Putnam, MD

650 Islet Cell Adenoma

Larissa V. Furtado, MD and Angelica R. Putnam, MD

652 Mesenchymal Hamartoma of Liver

Larissa V. Furtado, MD and Karen S. Thompson, MD

654 Nesidioblastosis

Larissa V. Furtado, MD

656 Nodular Regenerative Hyperplasia

Larissa V. Furtado, MD



SECTION 2: MALIGNANT PRIMARY

660 Fibrolamellar Hepatocellular Carcinoma

Angelica R. Putnam, MD and Larissa V. Furtado, MD

664 Hepatoblastoma

Larissa V. Furtado, MD, Karen S. Thompson, MD, and Angelica R. Putnam, MD

670 Pancreatoblastoma

Larissa V. Furtado, MD

674 Pediatric Hepatocellular Carcinoma

678 Solid Pseudopapillary Tumor

Sanjay Kakar, MD and Grace E. Kim, MD

682 Undifferentiated Embryonal Sarcoma

Karen S. Thompson, MD

PART XI: RENAL

SECTION 1: BENIGN

686 Cystic Nephroma

Angelica R. Putnam, MD and Stephen M. Bonsib, MD

690 Nephrogenic Rest and Nephroblastomatosis

Aliya N. Husain, MD

692 Ossifying Renal Tumor of Infancy

Karen S. Thompson, MD

694 Renal Metanephric Tumors

SECTION 2: MALIGNANT PRIMARY

700 Anaplastic Sarcoma

704 Clear Cell Sarcoma of Kidney

Jeremy C. Wallentine, MD

708 Congenital Mesoblastic Nephroma

Aliya N. Husain, MD

712 MiTF/TFE Family Translocation-Associated Carcinoma

Satish K. Tickoo, MD

720 Nephrogenic Tumors, Including Wilms

724 Renal Medullary Carcinoma

Karen S. Thompson, MD

726 Rhabdoid Tumor of Kidney

Jeremy C. Wallentine, MD and Karen S. Thompson, MD

730 Wilms Tumor

Angelica R. Putnam, MD



PART XIII: REPRODUCTIVE



SECTION 1: BENIGN

742 Thecoma-Fibroma

Silvia Skripenova, MD and Karen S. Thompson, MD

SECTION 2: MALIGNANT PRIMARY

746 Choriocarcinoma

750 Dysgerminoma

Silvia Skripenova, MD and Jeffrey L. Killeen, MD

752 Gonadoblastoma

Silvia Skripenova, MD and Jeffrey L. Killeen, MD

754 Juvenile Granulosa Cell Tumor

Silvia Skripenova, MD and Jeffrey L. Killeen, MD

756 Malignant Mixed Germ Cell Tumor

760 Sertoli-Leydig Cell Tumors

Silvia Skripenova, MD

764 Teratomas

Silvia Skripenova, MD

768 Yolk Sac Tumor

Silvia Skripenova, MD

Part XIII: HEMATOPOIETIC



SECTION 1: BORDERLINE

774 Hemophagocytic Syndrome

Jeremy C. Wallentine, MD

SECTION 2: MALIGANT PRIMARY

782 Acute Myeloid Leukemia

Kaaren K. Reichard, MD

792 Anaplastic Large Cell Lymphoma, ALK(+)

Jeremy C. Wallentine, MD

800 Autoimmune Lymphoproliferative Syndrome

L. Jeffrey Medeiros, MD, Sa A. Wang, MD, and Roberto N. Miranda, MD

812 B-Lymphoblastic Leukemia/Lymphoma

Qian-Yun Zhang, MD, PhD

820 Burkitt Lymphoma

Jeremy C. Wallentine, MD

826 Childhood Myelodysplastic Syndrome

Carla S. Wilson, MD, PhD

832 Classic Hodgkin Lymphoma

Jeremy C. Wallentine, MD

840 Diffuse Large B-Cell Lymphoma

Jeremy C. Wallentine, MD

846 Early T-Cell Precursor Acute Lymphoblastic Leukemia

David R. Czuchlewski, MD

848 Juvenile Myelomonocytic Leukemia

Devon Chabot-Richards, MD and Qian-Yun Zhang, MD, PhD

852 Mastocytosis

Jeremy C. Wallentine, MD

860 Myeloid Neoplasms With Germline Predisposition

David R. Czuchlewski, MD

862 Myeloid Proliferations Related to Down Syndrome

David R. Czuchlewski, MD

866 Myeloid Sarcoma

Jeremy C. Wallentine, MD

872 Nodular Lymphocyte-Predominant Hodgkin Lymphoma

Pei Lin, MD and L. Jeffrey Medeiros, MD

884 Overview of Lymphoproliferative Disorders Associated With Primary Immunodeficiency Disorders

L. Jeffrey Medeiros, MD, Keyur Patel, MD, PhD, and Roberto N. Miranda, MD

890 Pediatric-Type Follicular Lymphoma

Jeremy C. Wallentine, MD

894 Posttransplant Lymphoproliferative Disorders

Mohammad A. Vasef, MD

900 Primary Mediastinal (Thymic) Large B-Cell Lymphoma

Francisco Vega, MD, PhD, L. Jeffrey Medeiros, MD, and

Roberto N. Miranda, MD

910 T-Lymphoblastic Leukemia/Lymphoma

Mohammad A. Vasef, MD