Epidemiology of Cannabis: Genotoxicity, Neurotoxicity, Epigenomics and Aging provides a novel and comprehensive exploration of four areas that have previously been associated with cannabis use, namely mental health in adults and young adults, pediatric autism, congenital anomalies, and pediatric cancers, including testicular cancer. The book also explores the possibility of how these associations might be reflected in overall disease trends at the population health level. This book surveys these four areas in detail and applies cutting-edge analytical software and geospatial space time analytical techniques to these questions.With all this information gathered into one book in an easily readable form, this book is a reference for clinicians, health science and allied health practitioners, public health and basic science researchers and drug and health regulators interested in these topics. It is also suitable for inclusion in course work and study preparation courses at both the undergraduate and postgraduate levels.


SECTION 1: Mental Illness Close Parallels between Cannabis Use and Deteriorating US Mental Health at Four Levels Supports and Extends the Epidemiological Salience of Demonstrated Causal Mental Health Relationships: A Geospatiotemporal Study

1. National Trends

2. Regional Trends

3. State Trends

4. Sub-State Trends

5. Geospatial Analysis

6. Causality Criteria

SECTION 2: Autistic Spectrum Disorder Linked Rise of Cannabis Use and Autism Incidence Demonstrated by Close Three Level Geospatiotemporal Relationships, USA, 1990-2011.

7. National Trends

8. Regional Trends

9. State Trends

10. Geospatial Analysis

11. Changes in State Trends

12. Legal Status and Autism

13. Geospatial Analysis of Legal Status and Autism

SECTION 3: Congenital Anomalies Geotemporospatial Analysis of United States 38-44 Congenital Anomalies as a Function of Multiple Cannabinoid- and Substance- Exposure in the Decades of Cannabis Legalization: Phenocopying Thalidomide and Hundred Megabase-Scale Genotoxicity

14. Drug Use by Race

15. Drugs and Defects Overview

16. Chromosomal Anomalies: Anomalies 1:5

17. Gastroschisis: Anomaly 6

18. Atrial Septal Defect (Secundum): Anomaly 7

19. Cardiovascular Defects of Interest: Anomalies 8-11

20. Hawaiian - American Review: Anomalies 12-37

21. Conclusion: Time Course, Quintile Analysis, Canada, Thalidomide, Legal Status, Causality

SECTION 4: Cancer and Heritable Cancer Reflections of Heritable Cannabis-Related Genotoxicity in Rising Adult and Pediatric Cancer Rates Across USA in Time- and Ethnicity- Denominated Analyses

22. General Introduction and Overview

23. Sequential Analysis of Cancer Types

24. Geospatiotemporal Modelling - Fitted Values

25. Geospatiotemporal Modelling - Matrix Multiplication

26. Summary of Geospatiotemporal Modelling

27. Overall Conclusions

SECTION 5: Epigenetics and Aging As modern epigenetic studies provide profound insights into the observed pattern of teratological, cancerogenic and age-accelerated disease it becomes important to consider new findings in detail.

28. Epigenetics of Cannabinoids - Introduction

29. Epigenetics of Cannabinoids Historical Studies

30. Epigenetics of Cannabinoids Longitudinal Sperm Study - Overview

31. Epigenetics of Cannabinoids Longitudinal Sperm Study Stem Cells

32. Epigenetics of Cannabinoids Longitudinal Sperm Study - Chromosomes

33. Epigenetics of Cannabinoids Longitudinal Sperm Teratology - Brain

34. Epigenetics of Cannabinoids Longitudinal Sperm Teratology - Cardiovasculature

35. Epigenetics of Cannabinoids Longitudinal Sperm Teratology Other Organs

36. Epigenetics of Cannabinoids Longitudinal Sperm Study - Carcinogenesis

37. Epigenetics of Cannabinoids Accelerated Aging