Part I. Pharmacology of Cannabis and the Endocannabinoid System:

1. How cannabis works in the brain Ken Mackie

2. The function of the endocannabinoid system Nathan D. Winters and Sachin Patel

3. Synthetic cannabinoids Liana Fattore and Matteo Marti


Part II. The Changing Face of Cannabis:

4. The epidemiology of cannabis use and cannabis use disorder Deborah Hasin

5. Is cannabis becoming more potent? Tom P. Freeman and Sam Craft

6. Policy implications of the evidence on cannabis use and psychosis Wayne Hall and Louisa Degenhardt


Part III. Cannabis and the Brain:

7. The impact of pubertal exposure to cannabis on the brain: a focus on animal studies Erica Zemberletti and Tiziana Rubino

8. The impact of cannabis exposure on the adolescent brain: humans studies and translational insights Jacqueline-Marie Ferland, Alexandra Chisholm and Yasmin L. Hurd

9. Cannabis and cognition: an update on short- and long-term effects Lisa-Marie Greenwood, Valentina Lorenzetti and Nadia Solowij

10. Is there a cannabis-associated psychosis subtype? Lessons from biological typing in the b-snip project, and implications for treatment Godfrey Pearlson and Matcheri S. Keshavan


Part IV. Cannabis, Anxiety and Mood:

11. Cannabis and anxiety Grace Lethbridge, Beth Patterson and Michael Van Ameringen

12. Cannabis consumption and risk of depression and suicidal behaviour Gabriella Gobbi

13. Cannabis and bipolar disorder Jairo Pinto and Mauren Leticia Ziak


Part V. Cannabis and Psychosis:

14. Cannabis and psychosis proneness Rajiv Radhakrishnan, Shubham Kamal, Sinan Guloksuz and Jim van Os

15. Which cannabis users develop psychosis? Edoardo Spinazzola, Marta Di Forti and Robin M. Murray

16. Cannabis causes positive, negative, cognitive symptoms and produces impairments in electrophysiological indices of information processing Ashley Martin-Schnakenberg, Mohini Ranganathan and D. Cyril D'Souza


Part VI. Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications:

17. Does cannabis cause schizophrenia? Emmet Power, Colm Healy, Robin M. Murray and Mary Cannon

18. Postmortem studies of the brain cannabinoid system in schizophrenia Suresh Sundram, Brian Dean and David Copolov

19. The endocannabinoid system in schizophrenia Paul Morrison

20. Cannabidiol as a potential antipsychotic F. Markus Leweke and Cathrin Rohleder

21. Genetic explanations for the association between cannabis and schizophrenia Sarah M. Colbert and Emma Johnson


Part VII. Cannabis and its Impact on Schizophrenia:

22. Acute effects of cannabinoids in people with a psychotic illness Suhas Ganesh, Cécile Henquet, R. Andrew Sewell, Rebecca Kuepper, Mohini Ranganathan and Deepak Cyril D'Souza

23. Cannabis and the long-term course of schizophrenia Tabea SchoeleR

24. Treating cannabis use in schizophrenia and other psychotic disorders Alexandria S. Coles, Ashley E Kivlichian, David J. Castle and Tony P. George


Part VIII. Special Topics:

25. Prenatal cannabis exposure: associations with development and behavior Sarah E. Paul, Cynthia E. Rogers and Ryan Bogdan

26. Cannabis use and violence Giulia Trotta, Paolo Marino, Victoria Rodriguez, Robin M. Murray and Evangelos Vassos

27. Cannabis withdrawal Jane Metrik and Kayleigh McCarty

28. Cannabis and addiction Valerie Curran, Will Lawn and Tom P. Freeman

29. Tobacco use among cannabis users: insights into co-use and why it matters for people with psychosis Rachel A. Rabin, Erin A. McClure and Tony P. George

30. Cannabis addiction genetics Suhas Ganesh and Arpana Agrawal

31. Snoozing on pot: cannabis and sleep Patrick D. Skosnik and Toral S. Surti

32. Cannabinoids as medicines: what the evidence says and what it does not say Marco De Toffol, Elena Dragioti, Andre Ferrer Carvalho, and Marco Solmi.