Reviews emerging "lab-on-a-chip" miniaturization technologies
Covers micro-fabrication, 3D bio-printing and cell culture techniques, biosensor design and other technologies
Includes special focus on "organs-on-a-chip" and "cancer-on-a-chip" technologies
Summarizes special applications such as personalized medicine and detecting pathogens
Summary
Miniaturization in the fields of chemistry and molecular biology has resulted in the "lab-on-a-chip." Such systems are micro-fabricated devices capable of handling extremely small fluid volumes facilitating the scaling of single or multiple lab processes down to a microchip-sized format. The convergence of lab-on-a-chip technology with the field of cell biology facilitated the development of "organ-on-a-chip" systems. Such systems simulate the function of tissues and organs, having the potential to bypass some cell and animal testing methods. These technologies have generated high interest as applications for disease modeling and drug discovery.
This book, edited by Drs. Sean Murphy and Anthony Atala, provides a comprehensive coverage of the technologies that have been used to develop organ-on-a-chip systems. Known leaders cover the basics to the most relevant and novel topics in the field, including micro-fabrication, 3D bio-printing, 3D cell culture techniques, biosensor design and microelectronics, micro-fluidics, data collection, and predictive analysis. The book describes specific tissue types amenable for disease modeling and drug discovery applications. Lung, liver, heart, skin and kidney "on-a-chip" technologies are included as well as a progress report on designing an entire "body-on-a-chip" system. Additionally, the book covers applications of various systems for modeling tissue-specific cancers, metastasis, and tumor microenvironments; and provides an overview of current and potential applications of these systems to disease modeling, toxicity testing, and individualized medicine.
Table of Contents
Introduction
Microfabrication and 3-D Bioprinting of Organs-on-a-Chip
Prafulla Chandra, Carlos Kengla, Sang Jin Lee
Three-Dimensional Cell Culture
Ivy L. Mead, Colin E. Bishop
Electrochemical Sensors for Organs-on-a-Chip
Joyce Han-Ching Chiu, Ge-Ah Kim, Rodney Daniels
Microfluidics
Panupong Jaipan, Roger Narayan
From Big Data to Predictive Analysis from in vitro Systems
Andre Kleensang, Alexandra Maertens, Thomas Hartung
Lab-on-a-Chip Systems for Biomedical Applications
Peter Ertl
From 2D Culture to 3D Microchip Models: Trachea, Bronchi/bronchiole and Lung Biomimetic Models for Disease Modeling, Drug Discovery and Personalized Medicine
Joan E. Nichols,Stephanie P. Vega,Lissenya B. Argueta, Jean A. Niles, Michael Smith, Adrienne Eastaway, David Brown, Joaquin Cortiella
Liver and Liver Cancer-on-a-Chip
Aleksander Skardal
Heart-on-a-Chip
Megan L. McCain
Skin-on-a-Chip
Claire G. Jeong
Tissue Engineered Kidney Models
Erica P. Kimmerling, David L. Kaplan
Body-on-a-Chip
Mahesh Devarasetty, Steven D. Forsythe,Thomas D. Shupe, Aleksander Skardal, Shay Soker
Integrated Multi-Organoid Dynamics
Ran Li, Michelle B. Chen, Roger D. Kamm
Cancer Metastasis-on-a-Chip
Ran Li, Michelle B. Chen, Roger D. Kamm
Breast Cancer-on-a-Chip
Pierre-Alexandre Vidi, Sophie A. Lelièvre
Disease Modeling
Harry SalemUta Grieshammer, Kelly A. Shepard
In Vivo, In Vitro And Stem Cell Technologies To Predict Human Pharmacology and Toxicology
Harry Salem
Personalized Medicine
Elisa Cimetta, Michael Lamprecht, Sarindr Bhumiratana,Nafissa Yakubova,Nina Tandon