Applied Biopharmaceutics & Pharmacokinetics, Sixth Edition provides you with a basic understanding of the principles of biopharmaceutics and pharmacokinetics and applies these principles to drug product development, drug product performance and drug therapy. The revised and updated sixth edition is unique in teaching basic concepts that relate to understanding the complex issues associated with safe and efficacious drug therapy.

Written by authors who have both academic and clinical experience, Applied Biopharmaceutics & Pharmacokinetics will help you to:
Understand the basic concepts in biopharmaceutics and pharmacokinetics.
Use raw data and derive the pharmacokinetic models and parameters that best describe the process of drug absorption, distribution, and elimination
Critically evaluate biopharmaceutic studies involving drug product equivalency and unequivalency
Design and evaluate dosage regimens of drugs, using pharmacokinetic and biopharmaceutic parameters
Detect potential clinical pharmacokinetic problems and apply basic pharmacokinetic principles to solve them.

Preface

Glossary

1. Intrtoduction to Biopharmaceutics and Pharmacokinetics

2. Mathematical Fundamentals in Pharmacokinetics

3. One-compartment Open Model: Intravenous Bolus Administration
5. Intravenous Infusion

6. Drug Elimination and clearance

7. Pharmacokinetics of Oral Absorption

8. Multiple-Dosage Regimens

9. Monlinear Pharmacokinetics

10. Physiologic Drub Distribution and Protein Binding

11. Drug Elimination and Hepatic Clearance

12. Pharmacogenetics

13. Physioloic Factors Related to Drug Absorption

14. Biopharmaceutc Consideratins in Drug Product Desitgn and In Vitro Drug Product Performance

15. Drug Product Performance, In Vivo: Bioavailability and Bioequivalence

16. Impact of Drug Product Quality and Biopharmaceutics on Clincal Efficacy

17. Modified-Release Drug Products

18. Targeted Drug Delivery Symptoms and Biotechnological Products

19. Relationship Between Pharmacokeinetics and Pharmacodynamics

20. Application of Pharmacokinetics to Clinical Situations

21. Dose Adjustment in Renal and Hepatic Disease
Appendix A Statistics

Appendix B Applications of Computer in Pharmacokinetcs

Appendix C Solutions to Frequently Asked Questions (FAQs) and Learning Questions

Appendix D Guiding Prinicples for Human and Animal Research

Appendix E Popular Drugs and Pharmacokinetic Parameters

Index