DEDICATIONS ........................................................... v
PREFACE TO THE SECOND EDITION....................... vii
PREFACE TO THE FIRST EDITION ............................ ix
CONTRIBUTORS ...................................................... xv
ACKNOWLEDGMENTS .......................................... xvii
COLOR PLATES ................................................... xviii
I. THE STRUCTURE AND FUNCTION
OF THE SPLEEN
1 The Anatomy of the Spleen ......................... 3
Ronald A. Bergman, Paul M. Heidger, Jr.,
and Carol E. H. Scott-Conner
2 The Microanatomy
of the Mammalian Spleen:
Mechanisms of Splenic Clearance ........ 11
Fern Tablin, Jack K. Chamberlain,
and Leon Weiss
3 Splenic Microcirculatory Blood Flow
and Function with Respect
to Red Blood Cells ................................. 23
Alan C. Groom, Ian C. MacDonald,
and Eric E. Schmidt
4 The Immune Functions of the Spleen ........ 51
Morris O. Dailey
5 The Role of the Spleen in Hemostasis ....... 71
W. Jean Dodds
II. CHARACTERISTICS
OF THE DISORDERED SPLEEN
6 The Pathology of the Spleen ...................... 79
Mohammad A. Vasef and Charles E. Platz
7 Splenic Pooling and Survival
of Blood Cells ....................................... 107
Anthony J. Bowdler and Frank Gary Renshaw
8 Dilutional Anemia: Abnormalities of Blood
Volume in Disorders of the Spleen ...... 123
Anthony J. Bowdler and Frank Gary Renshaw
III. CLINICAL ASPECTS
OF DISORDERS OF THE SPLEEN
9 The Clinical Significance of the Spleen .. 139
Anthony J. Bowdler
10 Hyposplenism ...........................................157
Monty Seymour Losowsky
and Peter Nigel Foster
11 The Relationship of the Spleen
to Infection ...........................................175
Thomas C. Rushton, Geoffrey J. Gorse,
and Anthony J. Bowdler
12 Hemolysis and Thrombocytopenia .......... 193
David R. Anderson and John G. Kelton
13 Myeloproliferative Disorders ...................213
Michael T. Shaw
14 The Spleen
in Lymphoproliferative Disease .......... 223
Peter C. Raich
15 The Spleen in Sickle Cell Disease ...........251
Graham R. Serjeant
16 Imaging of Spleen Disorders ...................259
Mark R. Paley and Pablo R. Ros
17 Surgery of the Spleen ...............................281
Carol E. H. Scott-Conner,
Anne T. Mancino, and John Lawrence
INDEX .................................................................. 315