Biomarkers of Hip Implant Function brings together established and potential new biomarkers, critically evaluating their clinical usefulness based on recent evidence. Researchers will benefit from a comprehensive view of the topic to identify underexplored areas. Orthopedic surgeons and general practitioners will use the book to monitor implant performance and facilitate management of their patients. Additionally, the work will benefit engineers and joint implant manufacturers to guide improvements in design. This book will also be of interest to regulators and policymakers by helping them update their guidelines on follow-ups for hip implant recipients. Nearly all orthopedic surgeons have implanted a cobalt-chromium hip and most general practitioners have at least one patient with cobalt-chromium implant on their books. The recent worldwide controversy surrounding metal-on-metal hips means that advice on how to manage patients with these implants is of great interest to these professionals. Hence, this book is a welcomed addition to the conversation.



KEY FEATURES
Covers all established and candidate biomarkers of hip implant wear, periprosthetic infection, and toxicity
Summarises recent research into blood titanium levels associated with well-functioning and malfunctioning hip implants to aid implant revision decisions
Reviews over 50 cases of suspected systemic cobalt toxicity to raise awareness of its symptoms and clinical presentation, and guide investigations and treatment decisions


ABOUT THE EDITOR
Ilona Swiatkowska
Ilona Swiatkowska is an experienced researcher and editor who received her doctorate from University College London. Her academic work has centred around the local and systemic adverse effects of cobalt, chromium, and titanium in the setting of hip arthroplasty. The project was supervised by Professor Alister Hart of the Royal National Orthopaedic Hospital (Stanmore, United Kingdom), whose research into blood cobalt and chromium levels in recipients of hip replacements directly influenced the current MHRA guidelines concerning the follow-up of patients with metal-on-metal hips. Ilona has published a comprehensive review on titanium as a biomarker of implant wear and defined updated laboratory reference ranges for blood and plasma titanium concentrations associated with well-functioning titanium-based hip implants.
Affiliations and Expertise
University College London, United Kingdom


Part I: Foundational information

1. Introduction to hip implants and biomarker testing
Ilona Swiatkowska, Shiraz A. Sabah, Laura-Maria Horga and Alister J. Hart

2. Degradation of metal hip implants
Andrew R. Beadling, Anne Neville and Michael G. Bryant

3. Implant metals and their potential toxicity
Ilona Swiatkowska


Part II: Assessing hip implant function and risk of local and systemic adverse reactions

4. Markers of hip implant degradation: analytical considerations and clinical interpretation
Pascal-Andre Vendittoli, Angela Styhler and Ilona Swiatkowska

5. Biomarkers of compromised implant fixation
Reshid Berber, Benjamin Bloch, Peter James and Andrew Manktelow

6. Biomarkers of periprosthetic joint infection
Marc-Olivier Kiss and Vincent Masse

7. Hip implants and systemic cobalt toxicity: a comprehensive review with case studies
Ilona Swiatkowska, Obakanyin J. Akinfosile, Ravindra V. Badhe, Mark Barba, Mathew T. Mathew and Divya Bijukumar



Part III: Translational effect of biomarker research on clinical practice

8. Clinical guidelines on the use of biomarkers for surveillance of hip replacements
Harry Hothi, Reshid Berber, Shiraz A. Sabah and Alister J. Hart