This expert volume in the Diagnostic Pathology series is an excellent point-of-care resource for practitioners at all levels of experience and training. Covering all aspects of benign and malignant lesions of lymph nodes, and extranodal lymphomas, as well as malignancies of spleen, it incorporates the most recent clinical, pathologic, and molecular knowledge in this challenging field to provide a comprehensive overview of all key issues relevant to today's practice. Richly illustrated and easy to use, the third edition of Diagnostic Pathology: Lymph Nodes and Extranodal Lymphomas is a one-stop reference for accurate, complete pathology reports, ideal as a day-to-day reference or as a reliable training resource.
Table of Contents

SECTION 1: REACTIVE NONSPECIFIC

CHANGES

4 Reactive Follicular Hyperplasia

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

10 Reactive Paracortical Hyperplasia

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

SECTION 2: INFECTIOUS CAUSES OF

LYMPHADENITIS

20 Chronic Granulomatous Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

28 Suppurative Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

32 Mycobacterium tuberculosis Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

40 Atypical Mycobacterial Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

48 Mycobacterial Spindle Cell Pseudotumor

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

52 Cat-Scratch Disease

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

58 Bacillary Angiomatosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

64 Lymphogranuloma Venereum Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

68 Whipple Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

72 Syphilitic Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

78 Infectious Mononucleosis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

84 Histoplasma Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

90 Cryptococcus Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

94 Toxoplasma Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

100 Coccidioides Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

108 Herpes Simplex Lymphadenitis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

114 Cytomegalovirus Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

122 Human Immunodeficiency Virus Lymphadenitis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

SECTION 3: REACTIVE

LYMPHADENOPATHIES

134 Inflammatory Pseudotumor of Lymph Node

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

142 Progressive Transformation of Germinal Centers

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

148 Kikuchi-Fujimoto Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

158 Rosai-Dorfman Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

168 Kimura Disease

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

176 Unicentric Hyaline Vascular Variant Castleman

Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

182 Unicentric Plasma Cell Variant Castleman Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

188 Multicentric Castleman Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

196 Rheumatoid Arthritis-Related Lymphadenopathy

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

204 Sarcoid Lymphadenopathy

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

210 Dermatopathic Lymphadenopathy

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

216 Hemophagocytic Lymphohistiocytosis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

226 Lymphadenopathy Associated With Joint Prostheses

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

232 Lipid-Associated Lymphadenopathy

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

236 Lymphadenopathy Secondary to Drug-Induced

Hypersensitivity Syndrome

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

244 IgG4-Related Disease

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

254 Systemic Lupus Erythematosus

258 Sinus Histiocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

SECTION 4: HODGKIN LYMPHOMAS

264 Nodular Lymphocyte-Predominant Hodgkin

Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

276 Lymphocyte-Rich Classic Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

284 Nodular Sclerosis Hodgkin Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

294 Mixed Cellularity Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

300 Lymphocyte-Depleted Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 5: LEUKEMIA/LYMPHOMA OF

IMMATURE B- OR T-CELL LINEAGE

308 B-Lymphoblastic Leukemia/Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

318 T-Lymphoblastic Lymphoma/Leukemia

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 6: NODAL B-CELL LYMPHOMAS

328 Chronic Lymphocytic Leukemia/Small Lymphocytic

Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

334 Richter Syndrome

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

340 Lymphoplasmacytic Lymphoma and Waldenström

Macroglobulinemia

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

350 Nodal Marginal Zone B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

356 Nodal Follicular Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

368 Pediatric-Type Follicular Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

372 Mantle Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

378 Mantle Cell Lymphoma, Blastoid and Pleomorphic

Variants

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

384 Diffuse Large B-Cell Lymphoma, Not Otherwise

Specified

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

392 Diffuse Large B-Cell Lymphoma, Not Otherwise

Specified, Immunoblastic

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

398 T-Cell/Histiocyte-Rich Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

402 ALK(+) Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

408 EBV(+) Diffuse Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

414 HHV-8(+) Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

422 Burkitt Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

430 High-Grade B-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

436 B-Cell Lymphoma, Unclassifiable, Intermediate

Between Diffuse Large B-Cell Lymphoma and Classic

Hodgkin Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 7: EXTRANODAL B-CELL

LYMPHOMAS

448 Extranodal Marginal Zone Lymphoma of Mucosa-

Associated Lymphoid Tissue (MALT Lymphoma)

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

458 Extranodal Follicular Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

470 Primary Cutaneous Follicle Center Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

480 Primary Mediastinal (Thymic) Large B-Cell

Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

490 Primary Diffuse Large B-Cell Lymphoma of Central

Nervous System

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

500 Pyothorax-Associated Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

506 Primary Cutaneous Diffuse Large B-Cell Lymphoma,

Leg Type

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

514 Plasmablastic Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

524 Primary Effusion Lymphoma and Solid Variant of

Primary Effusion Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

532 Lymphomatoid Granulomatosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

542 Intravascular Large B-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

548 Plasmacytoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

556 Diffuse Large B-Cell Lymphoma of Testis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

562 Splenic Marginal Zone Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

570 Hairy Cell Leukemia

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

580 Hairy Cell Leukemia Variant

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

588 Splenic Diffuse Red Pulp Small B-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

596 Diffuse Large B-Cell Lymphoma Arising in the Spleen

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 8: NODAL T-CELL LYMPHOMAS

604 Peripheral T-Cell Lymphoma, Not Otherwise

Specified

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

614 Angioimmunoblastic T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

624 Adult T-Cell Leukemia/Lymphoma, HTLV-1(+)

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

634 ALK(+) Anaplastic Large Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

640 ALK(-) Anaplastic Large Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 9: EXTRANODAL NK-/T-CELL

LYMPHOMAS

648 Breast Implant-Associated Anaplastic Large Cell

Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

658 Extranodal NK-/T-Cell Lymphoma, Nasal Type

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

666 Hepatosplenic T-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

676 Enteropathy-Associated T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

684 Monomorphic Epitheliotropic Intestinal T-Cell

Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

692 Indolent T-Cell Lymphoproliferative Disorder of the

Gastrointestinal Tract

696 Subcutaneous Panniculitis-Like T-Cell Lymphoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

704 T-Cell Prolymphocytic Leukemia Involving Lymph

Node and Other Tissues

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

712 Primary Cutaneous ?/d T-Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

718 EBV(+) T- and NK-Cell Lymphoproliferative Disorders

of Childhood

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

722 Mycosis Fungoides

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

736 Sézary Syndrome

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

746 Primary Cutaneous Anaplastic Large Cell Lymphoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

752 Lymphomatoid Papulosis

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

758 Primary Cutaneous Acral CD8(+) Lymphoma

762 Primary Cutaneous CD8(+) Aggressive

Epidermotropic Cytotoxic T-Cell Lymphoma

766 Primary Cutaneous CD4(+) Small/Medium T-Cell

Lymphoproliferative Disorder

SECTION 10: IMMUNODEFICIENCYASSOCIATED

LYMPHOPROLIFERATIONS

772 Overview of Primary Immunodeficiency-Associated

Lymphoproliferative Disorders

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

778 Autoimmune Lymphoproliferative Syndrome

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

790 Immunomodulating Agent-Associated

Lymphoproliferative Disorders

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

798 Posttransplant Lymphoproliferative Disorder, Early

Lesions and Polymorphic

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

808 Posttransplant Lymphoproliferative Disorder,

Monomorphic

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

818 EBV(+) Mucocutaneous Ulcer

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 11:

GRANULOCYTIC/HISTIOCYTIC TUMORS

824 Myeloid/Monocytic Sarcoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

832 Blastic Plasmacytoid Dendritic Cell Neoplasm

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

840 Blastic T/Myeloid Neoplasm Associated With

ZMYM2-FGFR1

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

850 Cutaneous Mastocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

854 Systemic Mastocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

866 Histiocytic Sarcoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

876 Follicular Dendritic Cell Sarcoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

884 Interdigitating Dendritic Cell Sarcoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

890 Langerhans Cell Histiocytosis

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

902 Langerhans Cell Sarcoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

910 Erdheim-Chester Disease

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

SECTION 12: NONHEMATOPOIETIC

PROLIFERATIONS IN LYMPH NODE

916 Epithelial Inclusions in Lymph Node

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

922 Nevus Cell Inclusions in Lymph Node

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD

926 Vascular Transformation of Lymph Node Sinuses

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

930 Angiomyomatous Hamartoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

934 Palisaded Myofibroblastoma

L. Jeffrey Medeiros, MD and Roberto N. Miranda, MD

938 Metastatic Kaposi Sarcoma

Roberto N. Miranda, MD and L. Jeffrey Medeiros, MD