Magnetic Nanoparticles in Human Health and Medicine
Explores the application of magnetic nanoparticles in drug delivery, magnetic resonance imaging, and alternative cancer therapy

Magnetic Nanoparticles in Human Health and Medicine addresses recent progress in improving diagnosis by magnetic resonance imaging (MRI) and using non-invasive and non-toxic magnetic nanoparticles for targeted drug delivery and magnetic hyperthermia. Focusing on cancer diagnosis and alternative therapy, the book covers both fundamental principles and advanced theoretical and experimental research on the magnetic properties, biocompatibilization, biofunctionalization, and application of magnetic nanoparticles in nanobiotechnology and nanomedicine.

Chapters written by a panel of international specialists in the field of magnetic nanoparticles and their applications in biomedicine cover magnetic hyperthermia (MHT), MRI contrast agents, biomedical imaging, modeling and simulation, nanobiotechnology, toxicity issues, and more. Readers are provided with accurate information on the use of magnetic nanoparticles in diagnosis, drug delivery, and alternative cancer therapeutics featuring discussion of current problems, proposed solutions, and future research directions. Topics include current applications of magnetic iron oxide nanoparticles in nanomedicine and alternative cancer therapy: drug delivery, magnetic resonance imaging, superparamagnetic hyperthermia as alternative cancer therapy, magnetic hyperthermia in clinical trials, and simulating the physics of magnetic particle heating for cancer therapy. This comprehensive volume:

Covers both general research on magnetic nanoparticles in medicine and specific applications in cancer therapeutics
Discusses the use of magnetic nanoparticles in alternative cancer therapy by magnetic and superparamagnetic hyperthermia
Explores targeted medication delivery using magnetic nanoparticles as a future replacement of conventional techniques
Reviews the use of MRI with magnetic nanoparticles to increase the diagnostic accuracy of medical imaging
Magnetic Nanoparticles in Human Health and Medicine is a valuable resource for researchers in the fields of nanomagnetism, magnetic nanoparticles, nanobiomaterials, nanobioengineering, biopharmaceuticals nanobiotechnologies, nanomedicine, and biopharmaceuticals, particularly those focused on alternative cancer diagnosis and therapeutics.

1. An introduction to magnetic nanoparticles: from bulk to nanoscale magnetism and their applicative potential in human health and medicine

Costica Caizer1*, Shital Bonde2, and Mahendra Rai2



1West University of Timisoara, Department of Physics, Bd. V. Parvan no. 4, 300223 - Timisoara, Romania

2UGC-Basic Science Research Faculty, Department of Biotechnology, SGB Amravati University, Amravati - 444 602, Maharashtra, India





Part I. Current Biomedical Applications of Magnetic Nanoparticles



2. Magnetic nanoparticles in nanomedicine

Gabriela Fabiola Stiufiuc1, Cristian Iacovita2, Valentin Toma3, Rares Ionu? Stiufiuc2,3, Romulus Tetean1* and Constantin Mihai Lucaciu3



1 Faculty of Physics, "Babes-Bolyai" University, Cluj-Napoca, Romania

2MedFuture Research Center for Advanced Medicine, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania

3Faculty of Pharmacy, "Iuliu Hatieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania



3. Clustering of magnetic nanoparticles for nanomedicine

Giacomo Mandriota1, Riccardo Di Corato2*



1Istituto Italiano di Tecnologia, via Morego 30, 16163 Genoa, Italy

2CNR-IMM, Institute for Microelectronics and Microsystems, Via Monteroni - Campus Ecotekne, 73100 Lecce, Italy







4. Multifunctional bioactive magnetic scaffolds with tailored features for bone tissue engineering

Teresa Russo1*, Roberto De Santis1, Valentina Peluso2, Antonio Gloria1



1 Institute of Polymers, Composites and Biomaterials (IPCB) National Research Council of Italy

2 Department of Neurosciences, Reproductive and Odontostomatological Sciences, University of Naples Federico II , Naples, Italy



5. Magnetic nanoparticles in the development of polymer scaffolds for medical applications

Larissa Stieven Montagna, Ana Paula da Silva, Amanda de Sousa Martinez de Freitas, Ana Paula Lemes*

Polymers and Biopolymers Technology Laboratory, (TecPBio), Department of Science and Technology, Federal University of Sao Paulo, S o José dos Campos, SP, Brazil



6. Magnetic polymer colloids for ultrasensitive molecular imaging

Sundas Riaz1,

Sumera Khizar1,

Nasir M. Ahmad1*

Gul Shahnaz2

Noureddine Lebaz3

Abdelhamid Elaissari3*

1Polymer Research Lab, School of Chemical and Materials Engineering (SCME), National University of Sciences and Technology (NUST), H-12 Sector, Islamabad-44000, Pakistan

2Department of Pharmacy, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad-45320, Pakistan

3Univ Lyon, University Claude Bernard Lyon-1, CNRS, LAGEPP UMR-5007, 43 boulevard du 11 novembre 1918, F-69100, Villeurbanne, France





7. Iron oxide nanoparticles in anticancer drug delivery and imaging diagnostics

Miroslava Nedyalkova1*, Boyan Todorov1, Haruna L. Barazorda-Ccahuanac2,

Sergio Madurga3



1 Faculty of Chemistry and Pharmacy, Sofia University St. Kliment Ohridski , Sofia, Bulgaria

2 Centro de Investigación en Ingeniería Molecular-CIIM, Universidad Católica de Santa María, Arequipa, Perú

3 Faculty of Chemistry, Barcelona University, Barcelona, Spain



8. Functional addressable magnetic domains and their potential applications in theranostics

Sihomara Patricia García-Zepeda1, Jaime Santoyo-Salazar2*



1Toxicology Department, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-IPN, 07360 Mexico City, Mexico

2*Physics Department, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, CINVESTAV-IPN, 07360 Mexico City, Mexico





9. Nuclear/MR magnetic nanoparticle-based probes for multimodal biomedical imaging

Eirini Fragogeorgi1,2*, Sophia Sarpaki2, Maritina Rouchota2, Panagiotis Papadimitroulas2 and Maria Georgiou2



1Institute of Nuclear & Radiological Sciences, Technology, Energy & Safety (INRASTES), NCSR Demokritos , Ag. Paraskevi-Athens, Greece

2Bioemission Technology Solutions (BIOEMTECH), Lefkippos Attica Technology Park, NCSR Demokritos , Ag. Paraskevi-Athens, Greece







Part II. Magnetic Nanoparticles in Alternative Cancer Therapy



10. Magnetic nanoparticles hyperthermia: the past, the present and the future

Dawn Blazer, Yohannes Getahun, Ahmed A. El-Gendy*,



University of Texas El Paso, Department of Physics, El Paso, TX 79968, USA



11. Drug delivery and magnetic hyperthermia based on surface engineering of magnetic nanoparticles

Guilherme N. Lucena1,2,

Caio C. dos Santos1,

Gabriel C. Pinto1

Bruno E. Amantéa1,

Rodolfo D. Piazza1,

Miguel Jafelicci Jr1,

Rodrigo Fernando C. Marques1,2,3*



Laboratory of Magnetic Materials and Colloids, Department of Physical Chemistry, Institute of Chemistry, S o Paulo State University (UNESP), BRAZIL





12. Improving magneto-thermal energy conversion efficiency of magnetic fluids through external DC magnetic field induced orientational ordering

B. B. Lahiri, Surojit Ranoo, Fouzia Khan, John Philip

Smart Materials Section, Corrosion Science and Techonlogy Division, Materials Characterization Group, Metallurgy amd Materials Group, Indira Gandhi Centre for Atomic Research, Kalpakkam, Tamil Nadu, PIN 603102, India



13. Classical Magnetoliposomes vs Current Magnetociclodextrins with Ferrimagnetic Nanoparticle for High Efficiency and Low Toxicity in Alternative Therapy of Cancer by Magnetic/ Superparamagnetic Hyperthermia

Costica Caizer1*, Cristina Dehelean2, Codruta Soica2



1*West University of Timisoara, Faculty of Physics, Bv. V. Parvan no. 4, 300223 - Timisoara, Romania; e-mail: costica.caizer e-uvt.ro

2 Victor Babes University of Medicine and Pharmacy, Faculty of Pharmacy, P-zza. E. Murgu no. 2, 300041 Timisoara, Romania

2 Victor Babes University of Medicine and Pharmacy, Faculty of Pharmacy, P-zza. E. Murgu no. 2, 300041 Timisoara, Romania



14. Efficiency of energy dissipation in nanomagnets: a theoretical study of AC susceptibility

F. Vernay, J.-L. Déjardin, H. Kachkachi*

Université de Perpignan via Domitia, Lab. PROMES CNRS UPR8521, Rambla de la Thermodynamique, Tecnosud, 66100 Perpignan, France



15. Magnetic Nanoparticle Relaxation in Biomedical Application: Focus on Simulating Nanoparticle Heating

Ulrich M. Engelmann1,2*, Carolyn Shasha3, and Ioana Slabu2



1Department of MedicalEngineering and Applied Mathematics, FH Aachen University of Applied Sciences, Aachen, Germany

2Applied Medical Engineering, Helmholtz Institute, Medical Faculty, RWTH Aachen University,Aachen, Germany

3Department of Physics, University of Washington, Seattle, WA 98195, USA





16. Magnetic Nanoparticles in Alternative Tumors Therapy: Biocompatibility, Toxicity and Safety Compared with Classical Methods

Costica Caizer1 and Mahendra Rai2



1West University of Timisoara, Department of Physics, Bd. V. Parvan no. 4, 300223 - Timisoara, Romania

2UGC-Basic Science Research Faculty, Department of Biotechnology, SGB Amravati University, Amravati - 444 602, Maharashtra, India



17. The size, shape and composition design of iron oxide nanoparticles to combine MRI, magnetic hyperthermia and photothermia