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By James M. Ritter, DPhil FRCP FBPharmacolS FMedSci, Emeritus Professor of Clinical Pharmacology, King's College London, and Medical Research Director, Quintiles, London, UK; Rod J. Flower, PhD DSc FBPharmacolS FMedSci FRS, Professor, Biochemical Pharmacology, The William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London , London, UK; Graeme Henderson, BSc PhD FBPharmacolS FSB, Professor of Pharmacology, University of Bristol, Bristol, UK; Yoon Kong Loke, MB, BS, MRCP, MD, Senior Lecturer in Clinical Pharmacology, School of Medicine, Health Policy and Practice, University of East Anglia, Norwich, UK; David MacEwan and Humphrey P. Rang, MB BS MA DPhil Hon FBPharmacolS FMedSci FRS , Emeritus Professor of Pharmacology, University College London, London, UK