The incidence of primary and metastatic liver tumors is rising and the therapeutic armamentarium for these tumors is expanding at a rapid pace. Surgery remains the primary treatment modality for these tumors. With improvements in our perioperative management and operative techniques a larger proportion of patients are able to undergo potentially curative liver surgery. In addition, indications and criteria for liver transplantation for both primary and metastatic liver tumors are constantly expanding. Unfortunately, many patients are not amendable to surgical resection or liver transplantation and therefore alternative liver-directed therapies are routinely being implemented as part of complex multidisciplinary treatment models. However, these models are continually evolving as these regional therapeutic options continue to expand. New embolization agents and techniques, as well as, improvements in radiation delivery, are all evolving in the background of improvement in systemic and targeted therapy options for these tumors.
This book provides a comprehensive, state-of-the art review of the current state of liver-directed therapy for malignant liver tumors. The book will serve as a valuable resource for not only surgeons and clinicians but for researchers with an interest in malignant liver tumors. The book focuses on the therapeutic approach to primary and metastatic tumors providing an up-to-date review on surgical liver anatomy and new imaging techniques as well as patient selection and technical consideration for resection and transplantation. In addition, the book provides new insight into novel and evolving therapies in the areas of transarterial therapy such as: (i) bland embolization, (ii) chemoembolization, and (iii) radioembolization; as well as new radiation techniques including SBRT and proton therapy. Furthermore, the expanding role of hepatic artery infusion therapy in primary malignant tumors is highlighted. Finally, integration of all these regional therapy options with upcoming and evolving systemic and targeted therapy regimens are integrated and discussed. This book will serve as a very useful resource for clinicians and researchers managing and treating patients with these challenging malignancies. It provides a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters are written by experts in their fields and include the most up to date scientific and clinical information.


Table of contents (28 chapters)

Patient Selection and Technical Considerations

Zheleva, Vasilena (et al.)

Pages 3-13

Radiographic Assessment for Liver Tumors

Fouladi, Daniel (et al.)

Pages 15-33

Liver Transplantation for Hepatocellular Carcinoma: The Challenge of Organ Availability

Sonnenday, Christopher

Pages 37-43

Surgical Approach in Hepatocellular Carcinoma: Resection Versus Transplantation

Dhar, Vikrom K. (et al.)

Pages 45-55

Locoregional Therapies in the Management of Hepatocellular Carcinoma

Levey, Alexa O. (et al.)

Pages 57-72

Role of Radiation Therapy in Hepatocellular Carcinoma

Holliday, Emma B. (et al.)

Pages 73-89

Medical Therapy Options for Advanced Disease in Hepatocellular Carcinoma

Dika, Imane (et al.)

Pages 91-97

Guidelines for Resection of Intrahepatic Cholangiocarcinoma

Tang, Richard (et al.)

Pages 99-110

Regional Liver-Directed Therapies for Intrahepatic Cholangiocarcinoma

Murali, Nikitha (et al.)

Pages 111-123

Role of Radiation Therapy for Intrahepatic Cholangiocarcinoma

Patel, Sagar A. (et al.)

Pages 125-135

Current and Emerging Medical Therapies for Advanced Disease in Intrahepatic Cholangiocarcinoma

Deng, Aileen (et al.)

Pages 137-151

Pathological Classification and Surgical Approach to Hepatocellular Adenomas

Dokmak, Safi

Pages 153-167

Regional Therapies for Hepatic Adenoma

Silva, Jack P. (et al.)

Pages 169-175

Pathologic Classification of Preinvasive Cystic Neoplasms of the Intra- and Extrahepatic Bile Ducts

Quigley, Brian (et al.)

Pages 177-185

Indications for Resection of Preinvasive Cystic Neoplasms of the Intra- and Extrahepatic Bile Ducts

Abou-Khalil, Jad (et al.)

Pages 187-193

Patient Selection and Surgical Approach to Colorectal Cancer Liver Metastases

Cloyd, Jordan M. (et al.)

Pages 197-205

Ablative Techniques for Colorectal Cancer Liver Metastases

Correa-Gallego, Camilo (et al.)

Pages 207-215

Hepatic Arterial Therapy for Colorectal Cancer Liver Metastases

Bhutiani, Neal (et al.)

Pages 217-231

Hepatic Artery Infusion Therapy for Colorectal Cancer Liver Metastases

Correa-Gallego, Camilo (et al.)

Pages 233-242

Patient Selection and Surgical Approach to Neuroendocrine Tumor Liver Metastases

Keck, Kendall J. (et al.)

Pages 243-254

Liver-Directed Therapies for Neuroendocrine Metastases

Alexander, Erica S. (et al.)

Pages 255-265

Systemic Therapy for the Management of Neuroendocrine Tumor Liver Metastases

Kim, Stephanie M. (et al.)

Pages 267-277

Patient Selection and Guidelines for Resection and Liver-Directed Therapies: Non-colorectal, Non-neuroendocrine Liver Metastases

Fong, Zhi Ven (et al.)

Pages 279-287

Liver Transplantation for Other Cancers

Garcia-Aroz, Sandra (et al.)

Pages 291-309

Radiation Therapy for Liver Metastases

Amini, Arya (et al.)

Pages 311-322

MRI-Guided Laser Ablation of Liver Tumors

Nour, Sherif G.

Pages 323-332

Hepatic Artery Infusion Therapy for Primary Liver Tumors

Strand, Matthew S. (et al.)

Pages 333-371

Two-Stage Approach to Liver Resection

Wanis, Kerollos Nashat (et al.)