Builds on success and reputation of previous editions

Draws on the considerable teaching experience of an international author team, most notably the US and European Editors

The gold-standard European text for training, adopted by ESTRO as a course book, as a text for the Royal College of Radiologists' radiobiology exam and by courses in the US

Highly illustrated with new, 2 colour illustrations

Clear and concise style, appropriate for trainees and also practising radiation oncologists requiring a ready reference to the subject

Includes new chapters on stem cells, tissue response and the meeting point of meeting point of radiotherapy, radiobiology and physics
Summary
Basic Clinical Radiobiology is a concise but comprehensive textbook setting out the essentials of the science and clinical application of radiobiology for those seeking accreditation in radiation oncology, clinical radiation physics, and radiation technology.

Fully revised and updated to keep abreast of current developments in radiation biology and radiation oncology, this fifth edition continues to present in an interesting way the biological basis of radiation therapy, discussing the basic principles and significant developments that underlie the latest attempts to improve the radiotherapeutic management of cancer.

This new edition is highly illustrated with attractive 2-colour presentation and now includes new chapters on stem cells, tissue response and the convergence of radiotherapy, radiobiology, and physics. It will be invaluable for FRCR (clinical oncology) and equivalent candidates, SpRs (and equivalent) in radiation oncology, practicing radiation oncologists and radiotherapists, as well as radiobiologists and radiotherapy physicists.

Table of Contents
Introduction: The significance of radiobiology and radiotherapy for cancer treatment. Irradiation-induced damage and the DNA damage response. Cell death after irradiation: How, when and why cells die. Quantifying cell kill and cell survival. Radiation dose-response relationships. Linear energy transfer and relative biological effectiveness. Physics of radiation therapy for the radiobiologist. Tumour growth and response to radiation. Fractionation: The linear-quadratic approach. The linear-quadratic approach in clinical practice. Modified fractionation. Time factors in normal tissue responses to irradiation. The dose-rate effect. Pathogenesis of normal tissue side effects. Stem cells in radiotherapy. Normal tissue tolerance and the effect of dose inhomogeneities. The oxygen effect and therapeutic approaches to tumour hypoxia. The tumour microenvironment and cellular hypoxia responses. Combined radiotherapy and chemotherapy. Molecular targeted agents for enhancing tumour response. Biological individualisation of radiotherapy. Molecular image guided radiotherapy. Retreatment tolerance of normal tissues. Biological response modification of normal tissue reactions: Basic principles and pitfalls. Hadron therapy: The clinical aspects. Tissue response models. Second cancers after radiotherapy.