Encyclopedia of Cancer, Third Edition provides a comprehensive, up-to-date overview of the multiple facets of the disease, including research, treatment and societal impact. This new edition comprises 180 contributions from renown experts who present the latest in Mechanisms, Hallmarks of Cancer, Causes of Cancer, Prevention and Control, Diagnosis and Therapy, Pathology and the Genetics of specific Cancers. Readers will find a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health, all set alongside the latest advances and hot topics that have emerged since the previous edition.

Topics of interest in the field, including genomics and epigenomics, our understanding of the causes of cancer and the approaches to preventing it (e.g., HPV vaccination, role of obesity and nutrition, molecular markers of environmental exposures), new screening techniques (e.g., low-dose CT for lung cancer) and improvements in the treatment of many cancers (e.g., breast cancer, lung adenocarcinoma) are comprehensively and authoritatively presented.

Key Features
Comprises 180 contributions from renowned experts who present the latest in mechanisms, hallmarks of cancer, causes, prevention and control, diagnosis and therapy, pathology and genetics
Presents a comprehensive overview of the main areas of oncology, including etiology, mechanisms, prevention, and treatments, from basic science to clinical applications and public health
Readership
Oncologists; cancer researchers; oncology fellows in training; students and researchers in biology and epidemiology. Medical doctors other than oncologists and other cancer-related medical professionals will also benefit

Table of Contents

Mechanisms (edited by Gerd Pfeifer)
Ataxia Telangiectasia Syndrome

Hereditary Risk of Breast and Ovarian Cancer: BRCA1 and BRCA2

Li Fraumeni Syndrome

Carcinogenesis: Role of Reactive Oxygen and Nitrogen Species

Carcinogen-DNA adducts

Polyomaviruses in Human Cancer

Single Cell Sequencing and Tumor Heterogeneity

Driver Versus Passenger Mutations in Tumors

Mutational signatures and the aetiology of human cancers

Copy Number Variations in Tumors

Lynch Syndrome

WNT Signaling in Intestinal Cancer

Xeroderma Pigmentosum

Bloom's Syndrome

Mutations in DNA Methyltransferases and Demethylases

Mutations in Chromatin Remodeling Factors

Mutations in Histone Lysine Methyltransferases and Demethylases

Cataloguing DNA Methylation Changes in Tumors

Mechanisms of DNA Methylation Changes in Cancer

Defective 5-Methylcytosine Oxidation in Tumorigenesis

Biological Implications of DNA Methylation Changes in Cancer

Altered Histone Modifications in Cancer

Environmental Exposures and Epigenetic Perturbations

Enhancer Malfunction in Cancer

Epigenetic Therapy

Aberrations in the TCA Cycle

Molecular Mechanisms of Inflammation in Cancer

Animal Models in Cancer Research - Mechanisms

Rearrangements and Chromosome Translocations in Cancer

Genome Wide Association Studies (GWAS)

Oncogenesis by Unprogrammed Gene Activation: A Critical Evaluation of Cancer Testis Genes

Hormones and Cancer

Retinoblastoma

Microbiota and Colon Cancer: Orchestrating Neoplasia Through

DNA Damage and Immune Dysregulation

Cancer Metabolomics

Hallmarks of Cancer (edited by Marco Pierotti)

Cell Responses to DNA Damage

MAP Kinases

Biphasic Role of TGF- in Cancer Progression: From Tumor Suppressor to Tumor Promotor

TP53

Microenvironment Hallmarks

Adhesion

Tumors and Blood Vessel Interactions: a Changing Hallmark of Cancer

Warburg Effect

Glucose/Glucose Metabolism

Lactate/Lactate Transport

Glutamine Metabolism

Lipid Metabolism

Pyruvate Kinase

Mevalonate Pathway

Mitochondria

Yamanaka factors and iPS

Inflammation

Tumor-Associated Macrophages

Genetic Instability

DNA Damage Repair

Mismatch Repair: Biochemistry and Genetics

Senescence and Cellular Immortality

Telomere/Telomerase

Autophagy in Cancer

Anoikis

Epithelial to Mesenchyme Transition

Metastatic Signatures - The Tell-Tale Signs of Metastasis

Cancer Heterogeneity and Evolutionary Dynamics

Tunneling Nanotubes (TNTs)

Cancer Cell Death

Cancer System Biology

Causes of Cancer (edited by Graham A. Colditz)


Hepatitis C Virus (HCV)

HIV (Human Immunodeficiency Virus)

Papillomaviruses

Radiation

Aflatoxin

Dietary Factors and Cancer

Obesity

Physical Activity (lack of)

Ageing

Diabetes

Helicobacter Pylori

Opisthorchis, Clonorchis and cholangiocarcinoma

EBV

Chemical Carcinogens

Cancers as Ecosystems: From Cells to Population

Sleep Disturbance/Misalignment

Environmental Exposures

Prevention and Control (edited by Carlo La Vecchia)
Cancer Risk Reduction (Diet/Smoking Cessation/Lifestyle Changes)

Nutritional Supplements and Diet as Chemoprevention Agents

Chemoprevention Trials

Molecular Epidemiology and Cancer Risk

Cancer Survival and Survivorship

Tobacco Control

Nutrition, Obesity, and Metabolism

Environmental and Occupational Exposures

Cancer Disparities

Financial Burden of Cancer Care

Identification and Management of Hereditary Cancer Syndromes: a Public Health Priority

Chemoprevention

Aspirin

Diet and Diet Supplements

Metformin

Statins

Antioxidants

Cervical Cancer; Screening

Breast Cancer; Screening

Cancer in East Asia

Cancer in Sub-Saharan Africa

Cancer in South Asia

Cancer in Middle East

Cancer in Latin America

Cancer in Populations in Transition

Cancer in Migrants

Diagnosis and Therapy (edited by Marco Pierotti and Thomas Tursz)
Cancer Vaccines: Gene Therapy and Dendritic Cell-Based Vaccines

Interferons: Cellular and Molecular Biology of Their Actions

P-Glycoprotein-Mediated Multidrug Resistance

Hormone Resistance in Prostate Cancer

Estrogens and Antiestrogens

Immune Deficiency: Opportunistic Tumors

Targeting the Epigenome

End-of-Life Support

Symptom Control

Childhood Cancers: Global Approaches and New Perspectives

Oral Cancer

New Rationales and Designs for Clinical Trials in the Era of Precision Medicine

Thyroid Cancer

Precision Medicine

Acute Lymphocytic Leukemia; Diagnosis and Treatment

Acute Myelogenous Leukemia (in Adults and in Children); Diagnosis and Treatment

Myelodysplastic Syndrome; Diagnosis and Treatment

Esophageal Cancer; Diagnosis and Treatment

Gastric Cancer; Diagnosis and Treatment

Cancers of the Colorectum and Appendix; Diagnosis and Treatment

Cancers of the Pancreas; Diagnosis and Treatment

Cholangiocarcinoma; Diagnosis and Treatment

Cancer of the Uterine Cervix; Diagnosis and Treatment

Ovarian Cancer; Diagnosis and Treatment

Non-Small Cell Cancers of the Lung; Diagnosis and Therapy

Small Cell Cancer of the Lung; Diagnosis and Treatment

Renal Cancer; Diagnosis and Treatment

Pituitary Tumors; Diagnosis and Treatment

Tumors of the Adrenal Glands; Diagnosis and Treatment

Bladder Cancer; Diagnosis and Treatment

Cancers of the Oral Cavity; Diagnosis and Treatment

Cancers of the Larynx; Diagnosis and Treatment

Squamous Cell and Basal Cell Carcinoma; Diagnosis and Treatment

Malignant Melanomas: Diagnosis and Treatment

Tumors of the Eye and of the Orbita

Neuroblastoma; Diagnosis and Treatment

Germ Cell Tumors; Diagnosis and Treatment

Breast Cancer; Diagnosis and Treatment

Breast Cancer: Biology and Therapeutic Consequences

Bone and Soft Tissues Sarcomas; Diagnosis and Treatment

Bone and Soft Tissues Sarcomas; Biology

EBV-Related Malignancies; Diagnosis and Treatment

Hodgkin's Disease; Diagnosis and Treatment

Non-Hodgkin's Lymphoma; Diagnosis and Treatment

Naso-Pharyngeal Carcinoma

Advances in Cancer Imaging

Advances in Radiation Therapies

Glioblastoma: Biology, Diagnosis and Treatment

Immunology of Human Tumors

Acute Myeloblastic Leukemia

Prostate Cancer: Diagnosis and Treatment

Hallmarks

Non-Small Cell Cancers of the Lung; Biology and Therapeutic Consequences

Pathology and Genetics of Specific Cancers (edited by Fred Bosman)


Glioblastoma: Pathology and Genetics

Medulloblastoma

Esophageal Cancer; Pathology and Genetics

Gastric Cancer; Pathology and Genetics

Colorectal Cancer; Pathology and Genetics

Cancers of the Pancreas: Pathology and Genetics

Cancer of the Uterine Cervix; Pathology and Genetics

Ovarian Cancer; Pathology and Genetics

Non-Small Cell Cancers of the Lung; Pathology and Genetics

Small Cell Cancer of the Lung; Pathology and Genetics

Pituitary Tumors; Pathology and Genetics

Tumors of the Adrenal Glands; Pathology and Genetics

Parathyroid Cancer; Pathology and Genetics

Cancers of the Oral Cavity; Pathology and Genetics

Cancers of the Jaws; Pathology and Genetics

Cancers of the Larynx; Pathology and Genetics

Melanoma; Pathology and Genetics

Malignant Skin Adnexal Tumors; Pathology and Genetics

Cancers of the Eye and Orbita; Pathology and Genetics

Anal Cancer; Pathology and Genetics

Neuroblastoma; Pathology and Genetics

Wilms Tumor; Pathology and Genetics

Integrative Molecular Pathology

Chronic Lymphocytic Leukemia; Pathology and Genetics

Chronic Myelogenous Leukemia; Pathology and Genetics

Lymphoma, Hodgkin's; Pathology and Genetics

Lymphoma, non-Hodgkin's; Pathology and Genetics

Multiple Myeloma; Pathology and Genetics

Cancer of the Liver

Endometrial Cancer; Pathology and Genetics

Breast Cancer; Pathology and Genetics

Renal Cell Cancer; Pathology and Genetics

Prostate Cancer; Pathology and Genetics

Cancer of Bone and Joints

Germ Cell Tumors: Pathology and Genetics