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Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and growth and development in early life. This important resource highlights serotonins role in normal (unstressed) conditions and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. It also compares and contrasts physiological effects of brain and blood serotonin systems. Included is new data that suggests the influence of serotonin is in part through the regulation of gene expression this includes important proteins within the serotonin system itself, as well as proteins in interacting neurotransmitter systems. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension; and provides compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS).
Key Features Includes the latest information on new animal models of serotonin system dysfunction Explores the wide scope of serotonins influence on multiple organ and physiological systems Highlights the autonomous functioning of the brain and body serotonin systems Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy
Table of Contents BIOPHYSICS OF SEROTONIN 1. Biophysics of Serotonin and the Serotonin1A Receptor: Fluorescence and Dynamics Amitabha Chattopadhyay 2. Serotonin in plants: origin, function, and implications Praveen Saxena
ANATOMY 3. The anatomy of the serotonin system in different model systems: rat fish, flies and C. Elegans Patricia Gaspar and Christina Lillesaar 4. Serotonin in the endocrine pancreas Malin Fex 5. Serotonin and platelets Simone Marianne Schoenwaelder 6. Anatomy of the Serotonin Transporter Arnauld Belmer, Kate Beecher and Selena E. Bartlett
PHYSIOLOGY IN THE PERIPHERY 7. Cellular regulation of peripheral serotonin Damien Keating 8. Role of 5-HT in the control of gut motility Nicholas John Spencer 9. Phenotype of animals deficient in peripheral serotonin Michael Bader 10. Serotonin and immune system Luc Maroteaux and Anne Roumier 11. Serotonin and Adipocyte Function Malin Fex and Karin Stenkula 12. Serotonin and cardiovascular diseases Luc Maroteaux and Laurent Monassier 13. Involvement of 5-HT in afferent modulation of brainstem circuits regulating cardiovascular homeostasis Andrew Ramage and Patrick Hosford 14. Regulation of nociceptor signalling by serotonin Stefan Boehm and Isabella Salzer
PHYSIOLOGY IN THE BRAIN 15. Brain serotonin and energy homeostasis Yong Xu 16. Serotonin in central cardiovascular control Paul M. Pilowsky 17. Serotonin receptors and cardiovascular control Caroline Sevoz-Couche 18. Serotonin receptors as the therapeutic target for central nervous system disorders Yukihiro Ohno 19. Serotonin and the reconfiguration of the eupneic respiratory pattern Daniel Zoccal 20. Life without brain serotonin: phenotype of animals deficient in central serotonin synthesis Valentina Mosienko and Natalia Alenina