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Serotonin "The Mediator that Spans Evolution"

  • EDITOR Academic Press Ltd.
  • NIVEL Profesional
  • IDIOMAInglés
  • ISBN 978-0-12-800050-2
  • EAN 9780128000502
  • Colección -
  • Número -
  • Encuadernado Tapa Dura
  • Páginas 480
  • Largo -
  • Ancho -
  • Peso -
  • Fecha 28-11-2018
  • Número 1
  • Año 2018
Serotonin: The Mediator That Spans Evolution provides a comprehensive review of the widespread roles for serotonin in respiratory, cardiovascular and thermoregulatory control, and growth and development in early life. This important resource highlights serotonin’s role in normal (unstressed) conditions and in response to a variety of physiological stressors. It focuses on new animal models, comparing and contrasting data from mice and rats. It also compares and contrasts physiological effects of brain and blood serotonin systems. Included is new data that suggests the influence of serotonin is in part through the regulation of gene expression – this includes important proteins within the serotonin system itself, as well as proteins in interacting neurotransmitter systems. Finally, it discusses the role of serotonin system dysfunction in a variety of pathophysiological conditions, including sleep apnea, obesity and hypertension; and provides compelling evidence that this dysfunction is involved in Sudden Infant Death Syndrome (SIDS).

Key Features
Includes the latest information on new animal models of serotonin system dysfunction
Explores the wide scope of serotonin’s influence on multiple organ and physiological systems
Highlights the autonomous functioning of the brain and body serotonin systems
Provides compelling evidence of serotonin dysfunction in SIDS, a leading cause of death in infancy

Table of Contents
1. Biophysics of Serotonin and the Serotonin1A Receptor: Fluorescence and Dynamics
Amitabha Chattopadhyay
2. Serotonin in plants: origin, function, and implications
Praveen Saxena

3. The anatomy of the serotonin system in different model systems: rat fish, flies and C. Elegans
Patricia Gaspar and Christina Lillesaar
4. Serotonin in the endocrine pancreas
Malin Fex
5. Serotonin and platelets
Simone Marianne Schoenwaelder
6. Anatomy of the Serotonin Transporter
Arnauld Belmer, Kate Beecher and Selena E. Bartlett

7. Cellular regulation of peripheral serotonin
Damien Keating
8. Role of 5-HT in the control of gut motility
Nicholas John Spencer
9. Phenotype of animals deficient in peripheral serotonin
Michael Bader
10. Serotonin and immune system
Luc Maroteaux and Anne Roumier
11. Serotonin and Adipocyte Function
Malin Fex and Karin Stenkula
12. Serotonin and cardiovascular diseases
Luc Maroteaux and Laurent Monassier
13. Involvement of 5-HT in afferent modulation of brainstem circuits regulating cardiovascular homeostasis
Andrew Ramage and Patrick Hosford
14. Regulation of nociceptor signalling by serotonin
Stefan Boehm and Isabella Salzer

15. Brain serotonin and energy homeostasis
Yong Xu
16. Serotonin in central cardiovascular control
Paul M. Pilowsky
17. Serotonin receptors and cardiovascular control
Caroline Sevoz-Couche
18. Serotonin receptors as the therapeutic target for central nervous system disorders
Yukihiro Ohno
19. Serotonin and the reconfiguration of the eupneic respiratory pattern
Daniel Zoccal
20. Life without brain serotonin: phenotype of animals deficient in central serotonin synthesis
Valentina Mosienko and Natalia Alenina

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