Focuses on and targets specific clinical elements and the radiobiological aspects of head and neck cancer
Uses an interdisciplinary approach, encompassing clinical aspects of radiotherapy, radiation biology, and medical physics
Applies content by relating all radiobiological characteristics to their respective clinical implications
Explains the radiobiological rationale for all previous and current clinical trials for head and neck cancer


Summary
Common factors that lead to treatment failure in head and neck cancer are the lack of tumour oxygenation, the accelerated division of cancer cells during treatment, and radioresistance. These tumour-related challenges and possible ways to overcome them are covered in this book, authored by three medical physicists and a clinical oncologist who explain how different radiobiological findings have led to the development of various treatment techniques for head and neck cancer. Novel treatment techniques as supported by current scientific evidence are comprehensively explored, as well as the major challenges that arise in the retreatment of patients who have already undergone a form of radiotherapy for primary head and neck cancer.

Table of Contents
Foreword

Preface

Series Preface

Authors

Chapter 1. Introductory Aspects of Head and Neck Cancers

Chapter 2. Clinical Aspects of Head and Neck Cancer

Chapter 3. General Radiobiology Refresher

Chapter 4. Hypoxia and Angiogenesis

Chapter 5. The Mechanisms Behind Tumour Repopulation

Chapter 6. The Radiobiology and Radiotherapy of HPV-Associated Head and Neck Squamous Cell Carcinoma

Chapter 7. Normal Tissue Tolerance

Chapter 8. The Treatment of Head and Neck Cancer

Chapter 9. Targeted Therapies

Chapter 10. Retreatment Issues

Appendix: Radiobiological Modelling

References

Index