The Ovary, Third Edition includes over 60% new material and expands the sections dealing with clinical aspects of human ovarian functions and highlights advances in the areas of genomics, assisted reproductive technology, and cancer diagnosis and treatment. This new edition synthesizes all of this new information at the molecular, cellular, and organismal levels and presents modern ovarian physiology in a more understandable and comparative context.

The Ovary, Third Edition looks at ovarian function from a detailed molecular and cellular level. This work examines in detail all phases of the ovarian life cycle, placing special emphasis on the pathophysiology of the human ovary, including ovarian carcinogenesis.

Key Features
Represents an unparalleled compilation of chapters relevant to contemporary ovarian physiology
Provides basic and clinical research on ovarian function, abnormalities, assisted reproductive technology, and cancer
Highlights contemporary strategies and treatment paradigms in female factor infertility
Readership
Reproductive endocrinologists, physiologists, cell and molecular biologists, fertility/infertility specialists, as well as OB/GYNs

Table of Contents
Part I. The Ovarian Follicular Apparatus: Operational Characteristics
1. Follicle Selection in Mammalian Ovaries
2. Regulation of follicle formation and development by ovarian signaling pathway
3. Human Folliculogenesis Revisited: The Menstrual Cycle Visualized by Ultrasonography
4. Development of the Mammalian Ovary and Follicles
5. Organization of Ovarian Steroidogenic Cells and Cholesterol Metabolism
6. Inhibin, Activin and Follistatin in Ovarian Physiology
7. Cell-cell Interactions in the Ovarian Follicles: Role of TGF-beta Superfamily Members
8. Mutations and Polymorphisms, and their Functional Consequences, in Gonadotropin and Gonadotropin Receptor Genes
9. Environmentally Induced Epigenetic Transgenerational Inheritance of Ovarian Disease

Part II. Oocyte Maturation and Ovulation
10. Mammalian Oogenesis the fragile foundation of the next generation
11. Mammalian Oocyte Meiosis and Chromosome Stability
12. Oocyte Meiotic Maturation
13. Gene Expression During Oogenesis and Oocyte Development
14. Oocyte Development and Ovulation

Part III. The Corpus Luteum
15. Molecular Regulation of Progesterone Production in Corpus Luteum
16. Corpus Luteum Formation
17. Luteolysis and The Corpus Luteum of Pregnancy

Part IV. Novel Experimental Models
18. Transgenic Mouse Models in the Study of Ovarian Function
19. Genome-Wide Association Studies of Ovarian Function Disorders
20. Mitchondria Research in Human Reproduction
21. Reconstitution In Vitro of Oogenesis from Pluripotent Stem Cells
22. The Role of Mitochondria in Reproductive Function and Assisted Reproduction

Part V. Human Ovarian Pathophysiology: Select Aspects
23. Ovarian Hyperstimulation Syndrome
24. The Role of GnRH Agonist Triggering in GnRH Antagonist-Based Ovarian Stimulation Protocols
25. The Ovarian Factor in Assisted Reproductive Technology
26. The Role of Antimullerian Hormone in Assisted Reproduction
27. Polycystic Ovary Syndrome
28. Genetic and Environmental Factors in the Aetiology of Polycystic Ovary Syndrome
29. Germ Cell Failure and Ovarian Resistance: Human Genes and Disorders
30. Environmental Contaminants and Ovarian Toxicity
31. Autologous Transplantation of Human Ovarian Tissue
32. Oncofertility: Preservation of ovarian function after a cancer diagnosis

Part VI. Human Ovarian Cancer
33. Ovarian cancers: their varied origins and pathologically implicated microenvironment
34. Phenotypic Plasticity and the Origins and Progression of Ovarian Cancer
35. Novel Therapeutic Approaches and Targets for Ovarian Cancer
36. Molecular and Cellular Basis of Chemoresistance in Ovarian Cancer