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This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations.
Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors.
The most encyclopedic book on the pancreasproviding outstanding and clear guidance for the practicing clinician Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management Completely updated with brand new chapters Over 500 downloadable illustrations An editor and author team of high international repute who present global best-practice The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.
Contents
Contributors,
Preface to the Third Edition,
List of abbreviations,
Section 1: Anatomy of the Pancreas
1. Development of the pancreas and related structures Brian Lewis, Junhao Mao
2. Anatomy and the fine structure of the pancreas Daniel S. Longnecker, Fred Gorelick, Elizabeth D. Thompson
3. Congenital and inherited anomalies Martin Zenker, Markus M. Lerch
Section 2: Physiology and Pathophysiology of Pancreatic Functions
4. Physiology of acinus cell secretion Ole H. Petersen
5. Physiology of duct cell secretion Mei Zeng, Laura Vachel, Shmuel Muallem
13. Epidemiology and etiology of alcohol-induced pancreatitis Jeremy Wilson, Romano Pirola, Minoti Apte
14. Etiology and epidemiology of biliary acute pancreatitis Michael G. T. Raraty, Andrea Sheel, John Neoptolemos
15. Genetic factors in acute pancreatitis Zachary Zator, Georgios I. Papachristou
16. The role of the intestine and the mesenteric lymph in the development of SIRS and MODS in severe acute pancreatitis Alistair B. J. Escott, Anthony R. J. Phillips, John A. Windsor
17. Neuroinflammation in acute pancreatitis Jami L. Saloman, Kathryn M. Albers, Brian M. Davis
18. Molecular biochemical and metabolic abnormalities of acute pancreatitis Julia Mayerle, F. Ulrich Weiss, Walter Halangk, Markus M. Lerch
19. Histopathology of acute pancreatitis Günter Klöppel
20. Clinical classification systems of acute pancreatitis John A. Windsor, M. S. Petrov
21. Clinical assessment and biochemical markers to objectify severity and prognosis Bettina M. Rau, Guido Alsfasser
22. Acute pancreatitis associated with congenital anomalies Christopher R. Schlieve, Andrew L. Warshaw, Tracy C. Grikscheit
23. Acute pancreatitis in children Mark E. Lowe, Véronique D. Morinville
24. Acute pancreatitis associated with metabolic, infections and drug-related diseases Ali A. Aghdassi, Markus M. Lerch
25. Radiologic diagnosis and staging of severe acute pancreatitis Yoshihisa Tsuji
Clinical course and medical treatment of acute pancreatitis (2629)
26. Conservative therapy of acute pancreatitis: Volume substitution and enteral and parenteral nutrition Timothy B. Gardner
27. ICU treatment of severe acute pancreatitis Scott R. Gunn, David C. Whitcomb
28. The use of antibiotics in severe acute pancreatitis: Indications and limitations Rainer Isenmann, Mathias Wittau
29. Indication for interventional and surgical treatment of necrotizing pancreatitis Thomas E. Clancy
30. Management of infected pancreatic necroses: An endoscopic approach Eduardo Rodrigues-Pinto, Todd H. Baron
31. Minimal-invasive debridement and lavage of necrotizing pancreatitis Rebecca Saunders, Michael Raraty, Chris Halloran, John Neoptolemos
32. Open surgical debridement of necrotizing pancreatitis Lutz Schneider, Markus W. Büchler
34. Strategies of management of pseudo cysts and walled-off necroses after acute pancreatitis: Interventional endoscopic approach Georg Beyer, Julia Mayerle, Markus M. Lerch
35. Surgical treatment of pseudo cysts and walled-off necroses after acute pancreatitis Naohiro Sata, Masaru Koizumi, Alan K. Lefor
36. Management of fluid collection in acute pancreatitis Felix Lämmerhirt, Frank Ulrich Weiss, Markus M. Lerch
37. Management of pancreatic fistula in acute pancreatitis Jörg Kaiser, Thilo Hackert, Markus W. Büchler
38. Long-term outcome after acute pancreatitis Christin Tjaden, Thilo Hackert
Section 4: Chronic Pancreatitis
39. Molecular understanding of chronic pancreatitis John F. Eisses, Sohail Z. Husain
40. Epidemiology and pathophysiology of alcoholic chronic pancreatitis Atsushi Masamune, Tooru Shimosegawa
41. Pain mechanisms in chronic pancreatitis Pierluigi di Sebastiano, Tommaso Grottola, Francesco F. di Mola
42. Natural history of recurrent acute and chronic pancreatitis Rohit Das, Dhiraj Yadav
43. Chronic pancreatitis with inflammatory mass in the pancreatic head Ulrich F. Wellner, Tobias Keck
77. Evaluation of cystic lesions using EUS, MRT, and CT Anne Marie Lennon, Hiroyuki Maguchi
78. Cytologic evaluation of cystic neoplasm Martha Bishop Pitman
79. Natural history of cystic neoplasm: IPMN, MCN, SCN, and SPN Anna-Katharina Stadler, Thilo Hackert, Stefan Fritz, Markus W. Büchler
80. Surveillance or surgical treatment in asymptomatic cystic neoplasm Klaus Sahora, Carlos Fernández-del Castillo
Local and Standard Surgical Treatment of Cystic Neoplasms (8185)
81. Duodenum-preserving partial or total pancreatic head resection Hans G. Beger,Bertram Poch
82. Pancreatic middle segment resection of cystic neoplasms Calogero Iacono
83. Enucleation of cystic neoplasms: Indication and limitation Rosalie A. Carr, C. Max Schmidt, Henry A. Pitt
84. Standard surgical management of IPMN, MCN, SPN, and SCN lesions: An open approach Miral Sadaria Grandhi, Barish H. Edil, Richard D. Schulick
85. Surgical treatment of cystic neoplasm: Laparoscopic approach Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, Thilo Hackert
86. Management of recurrence of cystic neoplasm Zhi Ven Fong, Christopher L. Wolfgang, Keith D. Lillemoe
87. Long-term outcome after observation and surgical treatment of cystic neoplasm. What is the evidence? Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi
Section 7: Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer
88. Epidemiology of pancreatic cancer Evelina Mocci, Alison P. Klein
89. Smoking, a risk for pancreatic cancer: Experimental and clinical data Uwe A. Wittel, Bradley R. Hall , Surinder K. Batra
90. Molecular understanding of development of ductal pancreatic cancer Laura D. Wood, Ralph H. Hruban
91. Familial pancreatic cancer Alison P. Klein
92. Pathology of exocrine pancreatic tumors Meredith E. Pittman, Ralph H. Hruban
93. Pancreatic cancer: Precancerous lesions Michaël Noë, Lodewijk A. A. Brosens, Johan Offerhaus
94. Clinical history and risk factors of pancreatic cancer Norbert Hüser, Volker Aßfalg, Helmut Friess
95. Pancreatic cancer within uncinate process: Radiologic and clinical characteristics Sebastian Holländer, Dieter Birk
96. The role of EUS for diagnosis and differential diagnosis of neoplastic lesions Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao
97. Radiological diagnosis of pancreatic cancer: CT, MRI Siva P. Raman, Elliot K. Fishman
98. Screening of hereditary pancreatic cancer Michael Goggins
99. The role of PET in diagnosis of pancreatic cancer and cancer recurrence Norbert Hüser, Volker Aßfalg, Isabel Rauscher, Helmut Friess
101. The role of laparoscopy and peritoneal cytology in the management of pancreatic cancer Kyoichi Takaori, Shinji Uemoto
102. Clinical assessment and staging of advanced pancreatic cancer Jennifer LaFemina, Ann K. Friedrich, Giles F. Whalen
Surgical Treatment of Pancreatic Cancer (103110)
103. Pancreatic cancer: Indications for resection Akimasa Nakao
104. Pancreaticoduodenectomy for pancreatic cancer, short and long-term outcome after Kausch-Whipple and pylorus-preserving resection Jin He, John L. Cameron
105. Left pancreatectomy for body and tail cancer Georgios Gemenetzis, Christopher L. Wolfgang
106. Total pancreatectomy: Indication and limitations Seiko Hirono, Hiroki Yamaue
107. Laparoscopic and robotic resection for pancreatic cancer D. Magge, Herbert J. Zeh, Melissa E. Hogg
108. Extended radical surgery for pancreatic cancer Thilo Hackert, Alexis Ulrich, Markus W. Büchler
109. Palliative pancreaticoduodenectomy: Benefits and limitations Christoph W. Michalski, Max Heckler, Mert Erkan, Markus W. Büchler
110. Bypass surgery for advanced pancreatic cancer Jürgen Weitz, Thomas Pausch, Christoph W. Michalski, Thilo Hackert
111. Endoscopic and interventional palliation of pancreatic cancer Takao Itoi
112. Neoadjuvant treatment of pancreatic cancer: Downstaging results Robert A. Wolff, Gauri Varadhachary
113. Adjuvant chemotherapy in pancreatic cancer: First line and second line treatment: Benefits of survival Robert P. Jones, Paula Ghaneh, John P. Neoptolemos
114. Immunotherapy for pancreatic cancer Adrian G. Murphy, Elizabeth M. Jaffee, Lei Zheng
115. Targeted therapies for pancreatic cancer Vincent Bernard, Anirban Maitra
116. Palliative chemotherapy for advanced pancreatic cancer: Treatment modalities, side effects and benefits of survival Olusola O. Faluyi, Madhuchanda Chatterjee, Daniel H. Palmer
117. Management of pain in pancreatic cancer Michael Erdek
118. Role of radio and proton beam therapy for pancreatic cancer Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, Joseph M. Herman
119. Management of cancer recurrence Oliver Strobel, Markus W. Büchler
120. Survival and late morbidity after resection of pancreatic cancer Avinoam Nevler, Charles J. Yeo, Jordan M. Winter
Section 8: Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas
121. Epidemiology and classification of neuroendocrine tumors of the pancreas J. J. Mukherjee, Kok-Onn Lee, Gregory Kaltsas
122. Pathology of neuroendocrine tumors Atsuko Kasajima, Hironobu Sasano
123. Molecular genetic of neuroendocrine tumors Nickolas Papadopoulos, Ralph H. Hruban
124. Clinical manifestation of endocrine tumors of the pancreas Ken Kawabe, Tetsuhide Ito
125. Evidence of hormonal, laboratory, biochemistric and instrumental diagnostics of neuroendocrine tumors of the pancreas Kok-Onn Lee, Gregory Kaltsas, J. J. Mukherjee
126. Pancreatic neuroendocrine tumors in multiple neoplasia syndromes A. Rinke, T. M. Gress
Surgical Treatment of Endocrine Tumors of the Pancreas (130136)
130. Enucleation of neuroendocrine tumors Henning Dralle, Phuong Nguyen Thanh, Andreas Machens
131. Middle segment pancreatectomy and duodenum-preserving pancreatic head resection for neurendocrine tumors Hans G. Beger, Wataru Kimura
132. Major oncologic resection for neuroendocrine tumors Henning Dralle, Phuong Nguyen Thanh, Andreas Machens
133. Management of insulinoma Keijiro Ueda, Linkaku Lee, Tetsuhide Ito
134. Gastrinoma: Evidence of medical and surgical treatment Ryuichiro Doi
135. Rare neuroendocrine tumors of the pancreas: Management and evidence of surgical treatment Ryuichiro Doi
136. Treatment of neuroendocrine tumors of the pancreas and biliary tract Andrea Frilling, Ashley K. Clift, Vito Cicinnati
137. Long-term outcome after treatment of endocrine tumors Andreas Machens, Henning Dralle
Section 9: Periampullary Tumors and others than Pancreatic Cancer
138. Periampullary tumors: Clinical presentation and diagnostic strategy Amanda Cooper, Keith D. Lillemoe
139. Histology and genetics of cancer of the papilla, distal common bile duct and duodenum Yue Xue, Michelle D. Reid, Volkan Adsay
140. Adenoma and adenocarcinoma of the Ampulla of Vater: Diagnosis and management Omer Basar, William R. Brugge
141. Endoscopic treatment of adenomas of the Ampulla of Vater: Techniques, results, benefits and limitations Natsuyo Yamamoto, Hiroyuki Isayama, Kazuhiko Koike
142. Surgical treatment of adenoma and cancer of papilla Vater Hans G. Beger, Bertram Poch, Bettina M. Rau
143. Surgical treatment of duodenal cancer Fuyuhiko Motoi, Michiaki Unno
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