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The Pancreas "An Integrated Textbook of Basic Science, Medicine, and Surgery"

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This brand new updated edition of the most comprehensive reference book on pancreatic disease details the very latest knowledge on genetics and molecular biological background in terms of anatomy, physiology, pathology, and pathophysiology for all known disorders. Included for the first time, are two brand new sections on the key areas of Autoimmune Pancreatitis and Benign Cystic Neoplasms. In addition, this edition is filled with over 500 high-quality illustrations, line drawings, and radiographs that provide a step-by-step approach to all endoscopic techniques and surgical procedures. Each of these images can be downloaded via an online image bank for use in scientific presentations.

Every existing chapter in The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition has been thoroughly revised and updated to include the many changes in clinical practice since publication of the current edition. The book includes new guidelines for non-surgical and surgical treatment; new molecular biologic pathways to support clinical decision making in targeted treatment of pancreatic cancer; new minimally invasive surgical approaches for pancreatic diseases; and the latest knowledge of neuroendocrine tumors and periampullary tumors.

The most encyclopedic book on the pancreas—providing outstanding and clear guidance for the practicing clinician
Covers every known pancreatic disorder in detail including its anatomy, physiology, pathology, pathophysiology, diagnosis, and management
Completely updated with brand new chapters
Over 500 downloadable illustrations
An editor and author team of high international repute who present global best-practice
The Pancreas: An Integrated Textbook of Basic Science, Medicine and Surgery, 3rd Edition is an important book for gastroenterologists and gastrointestinal surgeons worldwide.

Contents

Contributors,

Preface to the Third Edition,

List of abbreviations,

Section 1: Anatomy of the Pancreas

1. Development of the pancreas and related structures
Brian Lewis, Junhao Mao

2. Anatomy and the fine structure of the pancreas
Daniel S. Longnecker, Fred Gorelick, Elizabeth D. Thompson

3. Congenital and inherited anomalies
Martin Zenker, Markus M. Lerch

Section 2: Physiology and Pathophysiology of Pancreatic Functions

4. Physiology of acinus cell secretion
Ole H. Petersen

5. Physiology of duct cell secretion
Mei Zeng, Laura Vachel, Shmuel Muallem

6. Pathophysiology of experimental pancreatitis
Vikas Dudeja, Rajinder Dawra, Ashok Saluja

7. Physiology and pathophysiology of function of sphincter of Oddi
Savio George Barreto, James Toouli

8. Neurohormonal and hormonal control of pancreatic secretion
Chung Owyang

9. Regulation of pancreatic protein synthesis and growth
Maria Dolors Sans, John A. Williams

10. Fibrogenesis of the pancreas: The role of stellate cells
Minoti V. Apte, Romano C. Pirola, Jeremy S. Wilson

11. Fibrogenesis of the pancreas: The role of macrophages
Aida Habtezion

12. Insulo-acinar relationship
Keiko Shiratori, Kyoko Shimizu

Section 3: Acute Pancreatitis

13. Epidemiology and etiology of alcohol-induced pancreatitis
Jeremy Wilson, Romano Pirola, Minoti Apte

14. Etiology and epidemiology of biliary acute pancreatitis
Michael G. T. Raraty, Andrea Sheel, John Neoptolemos

15. Genetic factors in acute pancreatitis
Zachary Zator, Georgios I. Papachristou

16. The role of the intestine and the mesenteric lymph in the development of SIRS and MODS in severe acute pancreatitis
Alistair B. J. Escott, Anthony R. J. Phillips, John A. Windsor

17. Neuroinflammation in acute pancreatitis
Jami L. Saloman, Kathryn M. Albers, Brian M. Davis

18. Molecular biochemical and metabolic abnormalities of acute pancreatitis
Julia Mayerle, F. Ulrich Weiss, Walter Halangk, Markus M. Lerch

19. Histopathology of acute pancreatitis
Günter Klöppel

20. Clinical classification systems of acute pancreatitis
John A. Windsor, M. S. Petrov

21. Clinical assessment and biochemical markers to objectify severity and prognosis
Bettina M. Rau, Guido Alsfasser

22. Acute pancreatitis associated with congenital anomalies
Christopher R. Schlieve, Andrew L. Warshaw, Tracy C. Grikscheit

23. Acute pancreatitis in children
Mark E. Lowe, Véronique D. Morinville

24. Acute pancreatitis associated with metabolic, infections and drug-related diseases
Ali A. Aghdassi, Markus M. Lerch

25. Radiologic diagnosis and staging of severe acute pancreatitis
Yoshihisa Tsuji

Clinical course and medical treatment of acute pancreatitis (26–29)

26. Conservative therapy of acute pancreatitis: Volume substitution and enteral and parenteral nutrition
Timothy B. Gardner

27. ICU treatment of severe acute pancreatitis
Scott R. Gunn, David C. Whitcomb

28. The use of antibiotics in severe acute pancreatitis: Indications and limitations
Rainer Isenmann, Mathias Wittau

29. Indication for interventional and surgical treatment of necrotizing pancreatitis
Thomas E. Clancy

30. Management of infected pancreatic necroses: An endoscopic approach
Eduardo Rodrigues-Pinto, Todd H. Baron

31. Minimal-invasive debridement and lavage of necrotizing pancreatitis
Rebecca Saunders, Michael Raraty, Chris Halloran, John Neoptolemos

32. Open surgical debridement of necrotizing pancreatitis
Lutz Schneider, Markus W. Büchler

33. Endoscopic treatment of biliary acute pancreatitis
Ichiro Yasuda, Shinpei Doi, Masatoshi Mabuchi

34. Strategies of management of pseudo cysts and walled-off necroses after acute pancreatitis: Interventional endoscopic approach
Georg Beyer, Julia Mayerle, Markus M. Lerch

35. Surgical treatment of pseudo cysts and walled-off necroses after acute pancreatitis
Naohiro Sata, Masaru Koizumi, Alan K. Lefor

36. Management of fluid collection in acute pancreatitis
Felix Lämmerhirt, Frank Ulrich Weiss, Markus M. Lerch

37. Management of pancreatic fistula in acute pancreatitis
Jörg Kaiser, Thilo Hackert, Markus W. Büchler

38. Long-term outcome after acute pancreatitis
Christin Tjaden, Thilo Hackert

Section 4: Chronic Pancreatitis

39. Molecular understanding of chronic pancreatitis
John F. Eisses, Sohail Z. Husain

40. Epidemiology and pathophysiology of alcoholic chronic pancreatitis
Atsushi Masamune, Tooru Shimosegawa

41. Pain mechanisms in chronic pancreatitis
Pierluigi di Sebastiano, Tommaso Grottola, Francesco F. di Mola

42. Natural history of recurrent acute and chronic pancreatitis
Rohit Das, Dhiraj Yadav

43. Chronic pancreatitis with inflammatory mass in the pancreatic head
Ulrich F. Wellner, Tobias Keck

44. Early stage chronic pancreatitis
Tetsuhide Ito, Masayuki Hijioka, Tooru Shimosegawa

45. Hereditary chronic pancreatitis: Molecular pattern, clinical consequences, management principles
Celeste Shelton, David C. Whitcomb

46. Epidemiology and pathophysiology of tropical chronic pancreatitis
Shailesh V. Shrikhande, Savio G. Barreto

47. Cystic fibrosis (CFTR)-associated pancreatic disease
Chee Y. Ooi, Aliye Uc

48. Clinical and laboratory diagnosis of chronic pancreatitis
Julia Mayerle, Peter Simon, Markus M. Lerch

49. Evidence of contrast enhanced CT and MRI/MRCP
J. Enrique Domínguez-Muñoz, Roberto García-Figueiras, Julio Iglesias-García

50. Chronic pancreatitis: Risk factors in cancer
Albert B. Lowenfels, Patrick Maisonneuve

51. Pain management of chronic pancreatitis
Kai Bachmann, Stephanie Plagemann, Yogesh Kumar Vashist, Jakob Robert Izbicki

52. Medical treatment of chronic pancreatitis: Pancreatic digestive enzymes: lipases, proteases
Mark E. Lowe

53. Nutritional support of chronic pancreatitis
Sinead N. Duggan, Stephen J. O’Keefe

54. Medical treatment of chronic pancreatitis: Antioxidants
Chris E. Forsmark

Strategies for surgical treatment of chronic pancreatitis (55–60)

55. Evidence of endoscopic and interventional treatment of chronic pancreatitis and pseudocysts
Jörg Schirra, Markus M. Lerch, Julia Mayerle

56. Indications and goals of surgical treatment
Ryan T. Groeschl, Michael B. Farnell

57. Pancreatic duct drainage procedure
D. Bausch, Tobias Keck

58. Duodenum preserving pancreatic head resection
Hans G. Beger, Bertram Poch, Yang Yinmo, Waldemar Uhl

59. Major pancreatic resection
May C. Tee, Michael B. Farnell

60. Laparoscopic surgery
Vernissia Tam, Melissa Hogg, Amer Zureikat

61. Chronic pancreatitis: Late outcome after medical and surgical treatment
Volker Aßfalg, Norbert Hüser, Helmut Friess

62. Management of pancreatic diabetes secondary to chronic pancreatitis
Keiko Shiratori

Section 5: Autoimmune Pancreatitis

63. Epidemiology of autoimmune pancreatitis
Terumi Kamisawa, Tooru Shimosegawa

64. Pathogenesis of autoimmune pancreatitis
Yoh Zen

65. Histology of autoimmune pancreatitis
Rajib Gupta, Vikram Deshpande

66. Clinical manifestation of type 1 autoimmune pancreatitis
Tooru Shimosegawa, Morihisa Hirota, Atsushi Kanno

67. Clinical manifestation of type 2 autoimmune pancreatitis
Emma L. Culver, George Webster

68. Laboratory diagnosis of autoimmune pancreatitis
J.-Matthias Löhr, Pia Maier, Stephan L. Haas

69. What is the evidence measuring immune markers
Shigeyuki Kawa

70. Imaging diagnosis of autoimmune pancreatitis
Kazuichi Okazaki, Tsukasa Ikeura, Kazushige Uchida, Makoto Takaoka

71. Medical treatment of autoimmune pancreatitis
Shounak Majumder, Suresh T. Chari

72. Long-term outcomes after treatment of autoimmune pancreatitis
Luca Frulloni, Nicolò de Pretis

Section 6: Neoplastic Tumors of the Exocrine Tissue: Benign Cystic Neoplasms of the Pancreas

73. Epidemiology of cystic neoplasm of the pancreas
Saurabh Mukewar, Suresh Chari

74. Histologic classification and staging of cystic neoplasm
Noriyoshi Fukushima, Giuseppe Zamboni

75. Molecular mechanisms of cystic neoplasm
Nickolas Papadopoulos, Ralph H. Hruban

76. Clinical presentation of cystic neoplasm
Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao

77. Evaluation of cystic lesions using EUS, MRT, and CT
Anne Marie Lennon, Hiroyuki Maguchi

78. Cytologic evaluation of cystic neoplasm
Martha Bishop Pitman

79. Natural history of cystic neoplasm: IPMN, MCN, SCN, and SPN
Anna-Katharina Stadler, Thilo Hackert, Stefan Fritz, Markus W. Büchler

80. Surveillance or surgical treatment in asymptomatic cystic neoplasm
Klaus Sahora, Carlos Fernández-del Castillo

Local and Standard Surgical Treatment of Cystic Neoplasms (81–85)

81. Duodenum-preserving partial or total pancreatic head resection
Hans G. Beger,Bertram Poch

82. Pancreatic middle segment resection of cystic neoplasms
Calogero Iacono

83. Enucleation of cystic neoplasms: Indication and limitation
Rosalie A. Carr, C. Max Schmidt, Henry A. Pitt

84. Standard surgical management of IPMN, MCN, SPN, and SCN lesions: An open approach
Miral Sadaria Grandhi, Barish H. Edil, Richard D. Schulick

85. Surgical treatment of cystic neoplasm: Laparoscopic approach
Richard A. Burkhart, Christopher L. Wolfgang, Markus W. Büchler, Thilo Hackert

86. Management of recurrence of cystic neoplasm
Zhi Ven Fong, Christopher L. Wolfgang, Keith D. Lillemoe

87. Long-term outcome after observation and surgical treatment of cystic neoplasm. What is the evidence?
Giovanni Marchegiani, Giuseppe Malleo, Claudio Bassi

Section 7: Neoplastic Tumors of Exocrine Tissue: Pancreatic Cancer

88. Epidemiology of pancreatic cancer
Evelina Mocci, Alison P. Klein

89. Smoking, a risk for pancreatic cancer: Experimental and clinical data
Uwe A. Wittel, Bradley R. Hall , Surinder K. Batra

90. Molecular understanding of development of ductal pancreatic cancer
Laura D. Wood, Ralph H. Hruban

91. Familial pancreatic cancer
Alison P. Klein

92. Pathology of exocrine pancreatic tumors
Meredith E. Pittman, Ralph H. Hruban

93. Pancreatic cancer: Precancerous lesions
Michaël Noë, Lodewijk A. A. Brosens, Johan Offerhaus

94. Clinical history and risk factors of pancreatic cancer
Norbert Hüser, Volker Aßfalg, Helmut Friess

95. Pancreatic cancer within uncinate process: Radiologic and clinical characteristics
Sebastian Holländer, Dieter Birk

96. The role of EUS for diagnosis and differential diagnosis of neoplastic lesions
Susumu Hijioka, Kazuo Hara, Nobumasa Mizuno, Nozomi Okuno, Kenji Yamao

97. Radiological diagnosis of pancreatic cancer: CT, MRI
Siva P. Raman, Elliot K. Fishman

98. Screening of hereditary pancreatic cancer
Michael Goggins

99. The role of PET in diagnosis of pancreatic cancer and cancer recurrence
Norbert Hüser, Volker Aßfalg, Isabel Rauscher, Helmut Friess

100. Tumor markers in pancreatic malignancies
Shin Hamada, Atsushi Masamune, Tooru Shimosegawa

101. The role of laparoscopy and peritoneal cytology in the management of pancreatic cancer
Kyoichi Takaori, Shinji Uemoto

102. Clinical assessment and staging of advanced pancreatic cancer
Jennifer LaFemina, Ann K. Friedrich, Giles F. Whalen

Surgical Treatment of Pancreatic Cancer (103–110)

103. Pancreatic cancer: Indications for resection
Akimasa Nakao

104. Pancreaticoduodenectomy for pancreatic cancer, short and long-term outcome after Kausch-Whipple and pylorus-preserving resection
Jin He, John L. Cameron

105. Left pancreatectomy for body and tail cancer
Georgios Gemenetzis, Christopher L. Wolfgang

106. Total pancreatectomy: Indication and limitations
Seiko Hirono, Hiroki Yamaue

107. Laparoscopic and robotic resection for pancreatic cancer
D. Magge, Herbert J. Zeh, Melissa E. Hogg

108. Extended radical surgery for pancreatic cancer
Thilo Hackert, Alexis Ulrich, Markus W. Büchler

109. Palliative pancreaticoduodenectomy: Benefits and limitations
Christoph W. Michalski, Max Heckler, Mert Erkan, Markus W. Büchler

110. Bypass surgery for advanced pancreatic cancer
Jürgen Weitz, Thomas Pausch, Christoph W. Michalski, Thilo Hackert

111. Endoscopic and interventional palliation of pancreatic cancer
Takao Itoi

112. Neoadjuvant treatment of pancreatic cancer: Downstaging results
Robert A. Wolff, Gauri Varadhachary

113. Adjuvant chemotherapy in pancreatic cancer: First line and second line treatment: Benefits of survival
Robert P. Jones, Paula Ghaneh, John P. Neoptolemos

114. Immunotherapy for pancreatic cancer
Adrian G. Murphy, Elizabeth M. Jaffee, Lei Zheng

115. Targeted therapies for pancreatic cancer
Vincent Bernard, Anirban Maitra

116. Palliative chemotherapy for advanced pancreatic cancer: Treatment modalities, side effects and benefits of survival
Olusola O. Faluyi, Madhuchanda Chatterjee, Daniel H. Palmer

117. Management of pain in pancreatic cancer
Michael Erdek

118. Role of radio and proton beam therapy for pancreatic cancer
Amol K. Narang, Lauren M. Rosati, Michael D. Chuong, Joseph M. Herman

119. Management of cancer recurrence
Oliver Strobel, Markus W. Büchler

120. Survival and late morbidity after resection of pancreatic cancer
Avinoam Nevler, Charles J. Yeo, Jordan M. Winter

Section 8: Neoplastic Tumors of the Endocrine Pancreas: Neuroendocrine Tumors of the Pancreas

121. Epidemiology and classification of neuroendocrine tumors of the pancreas
J. J. Mukherjee, Kok-Onn Lee, Gregory Kaltsas

122. Pathology of neuroendocrine tumors
Atsuko Kasajima, Hironobu Sasano

123. Molecular genetic of neuroendocrine tumors
Nickolas Papadopoulos, Ralph H. Hruban

124. Clinical manifestation of endocrine tumors of the pancreas
Ken Kawabe, Tetsuhide Ito

125. Evidence of hormonal, laboratory, biochemistric and instrumental diagnostics of neuroendocrine tumors of the pancreas
Kok-Onn Lee, Gregory Kaltsas, J. J. Mukherjee

126. Pancreatic neuroendocrine tumors in multiple neoplasia syndromes
A. Rinke, T. M. Gress

127. Non-functioning neuroendocrine tumors: Diagnosis and management principles
Takao Ohtsuka, Hideyo Kimura, Masafumi Nakamura

128. Medical and nucleotid treatment of neuroendocrine tumors of the pancreas
Gregory Kaltsas, J. J. Mukherjee, Kok-Onn Lee

129. Interventional radiology treatment of neuroendocrine tumors
Takao Ohtsuka, Hideyo Kimura, Masafumi Nakamura

Surgical Treatment of Endocrine Tumors of the Pancreas (130–136)

130. Enucleation of neuroendocrine tumors
Henning Dralle, Phuong Nguyen Thanh, Andreas Machens

131. Middle segment pancreatectomy and duodenum-preserving pancreatic head resection for neurendocrine tumors
Hans G. Beger, Wataru Kimura

132. Major oncologic resection for neuroendocrine tumors
Henning Dralle, Phuong Nguyen Thanh, Andreas Machens

133. Management of insulinoma
Keijiro Ueda, Linkaku Lee, Tetsuhide Ito

134. Gastrinoma: Evidence of medical and surgical treatment
Ryuichiro Doi

135. Rare neuroendocrine tumors of the pancreas: Management and evidence of surgical treatment
Ryuichiro Doi

136. Treatment of neuroendocrine tumors of the pancreas and biliary tract
Andrea Frilling, Ashley K. Clift, Vito Cicinnati

137. Long-term outcome after treatment of endocrine tumors
Andreas Machens, Henning Dralle

Section 9: Periampullary Tumors and others than Pancreatic Cancer

138. Periampullary tumors: Clinical presentation and diagnostic strategy
Amanda Cooper, Keith D. Lillemoe

139. Histology and genetics of cancer of the papilla, distal common bile duct and duodenum
Yue Xue, Michelle D. Reid, Volkan Adsay

140. Adenoma and adenocarcinoma of the Ampulla of Vater: Diagnosis and management
Omer Basar, William R. Brugge

141. Endoscopic treatment of adenomas of the Ampulla of Vater: Techniques, results, benefits and limitations
Natsuyo Yamamoto, Hiroyuki Isayama, Kazuhiko Koike

142. Surgical treatment of adenoma and cancer of papilla Vater
Hans G. Beger, Bertram Poch, Bettina M. Rau

143. Surgical treatment of duodenal cancer
Fuyuhiko Motoi, Michiaki Unno

144. Surgical treatment of distal cholangiocarcinoma
Yukihiro Yokoyama, Tomoki Ebata, Masato Nagino

145. Adjuvant and palliative chemotherapy of periampullary cancer: First line treatment and outcome
Eyas Mohamed, Paula Ghaneh, John Neoptolemos

146. Long-term survival after resection of periampullary cancer
Masayuki Ohtsuka, Masaru Miyazaki

Section 10: Transplantation of the Pancreas

147. Transplantation of pancreatic islets
Bernhard J. Hering, Melena D. Bellin

148. Transplantation of the pancreas
Hans W. Sollinger, Dixon B. Kaufman

Index, xxx