Features

Critically analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential
Discusses theranostics as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy
Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer
Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them
Summary

Recent advances in immunology and biology have opened new horizons in cancer therapy, included in the expanding array of cancer treatment options, which are immunotherapies, or cancer vaccines, for both solid and blood borne cancers. Cancer Vaccines: From Research to Clinical Practice is the first text in the field to bring immunotherapy treatments from the laboratory trial to the bedside for the practicing oncologist.

Cancer Vaccines: From Research to Clinical Practice:

Analyzes the most promising classes of investigational immunotherapies, integrating their scientific rationale and clinical potential
Discusses "theranostics" as pertaining to immunotherapy, i.e., using molecular diagnostics to identify patients that would most likely benefit from a therapy
Presents the new paradigm of biomarker guided R&D and clinical development in immunotherapy of cancer
Reviews bottlenecks in translational process of immunotherapies and offers strategies to resolve them

Table of Contents

SECTION I - Basic Aspects: Tumor Antigens and Preclinical Modelling

1. Factoring in antigen processing in designing anti-tumor T-cell vaccines, Lévy, Colombetti, Janda, Chapatte, Alves, Casado, Lévy and Peitrequin

2. Outlining the gap between preclinical models and clinical situation, Daniel L. Levey

SECTION II - Cell Based, Anti-infectious and Personalized Vaccines

3. THERAPEUTIC AND PROPHYLACTIC CANCER VACCINES - EMERGING PERSPECTIVES FROM ALLOGENEIC AND INFECTIOUS DISEASE VACCINES, Srinivasan

4. Personalized Cancer Vaccines, Teofilovici, Wentworth

5. Dendritic cell vaccines for gliomas, Luptrawan, Liu, S. Yu and Brian

III. INTRACEREBRAL HEMORRHAGE (ICH)

6. Peptide based active immunotherapy in cancer, Schroter and Minev

7. Multimodality Immunization Approaches to Improve on DNA Vaccines for Cancer, Qiu and Smith

8. Bidirectional Bedside Lab Bench Processes and Flexible Trial Design as a Means to Expedite the Development of Novel Immunotherapeutics, Bot and Obrocea

9. Diagnostic approaches for selecting patient-customized therapies, obviating tumor variability to maximize therapeutic effect, Chang, Kertesz, Liu