The structure, functions, and interactions of myeloid cells have long been the focus of research and therapeutics development. Yet, much more remains to be discovered about the complex web of relationships that makes up the immune systems of animals. Scientists today are applying genome-wide analyses, single-cell methods, gene editing, and modern imaging techniques to reveal new subclasses of differentiated myeloid cells, new receptors and cytokines, and important interactions among immune cells.

In Myeloid Cells in Health and Disease: A Synthesis, Editor Siamon Gordon has assembled an international team of esteemed scientists to provide their perspectives of myeloid cells during innate and adaptive immunity. The book begins by presenting the foundational research of Paul Ehrlich, Elie Metchnikoff, and Donald Metcalf. The following chapters discuss evolution and the life cycles of myeloid cells; specific types of differentiated myeloid cells, including macrophage differentiation; and antigen processing and presentation. The rest of the book is organized by broad topics in immunology, including

the recruitment of myeloid and other immune cells following microbial infection

the role of myeloid cells in the inflammation process and the repair of damaged tissue

the vast arsenal of myeloid cell secretory molecules, including metalloproteinases, tumor necrosis factor, histamine, and perforin

receptors and downstream signaling pathways that are activated following ligand-receptor binding

roles of myeloid cells during microbial and parasite infections

contributions of myeloid cells in atherosclerosis

myeloid-derived suppressor cells in tumor development and cancer

Myeloid Cells in Health and Disease: A Synthesis will benefit graduate students and researchers in immunology, hematology, microbial pathogenesis, infectious disease, pathology, and pharmacology. Established scientists and physicians in these and related fields will enjoy the book's rich history of myeloid cell research and suggestions for future research directions and potential therapies

Contributors

Preface

Acknowledgments

About the Editor

SECTION I INTRODUCTION AND HISTORY

1 Paul Ehrlich and the Early History of Granulocytes

A. Barry Kay

2 The Phagocyte, Metchnikoff, and the Foundation of Immunology

Giuseppe Teti, Carmelo Biondo, and Concetta Beninati

3 Growth and Differentiation Factors

Donald Metcalf and Nicos A. Nicola

SECTION II GENERAL ASPECTS

4 Evolution of Myeloid Cells

Daniel R. Barreda, Harold R. Neely, and Martin F. Flajnik

5 Advances on Myeloid Like-Cell Origins and Functions in the Model Organism Drosophila melanogaster

Laure El Chamy, Nicolas Matt, and Jean-Marc Reichhart

6 Monocyte, Macrophage, and Dendritic Cell Development: the Human Perspective

Matthew Collin and Venetia Bigley

7 Myeloid Cell Turnover and Clearance

William J. Janssen, Donna L. Bratton, Claudia V. Jakubzick, and Peter M. Henson

SECTION III SPECIALIZATION

8 Transcriptional Regulation and Macrophage Differentiation

David A. Hume, Kim M. Summers, and Michael Rehli

9 Murine Monocytes: Origins, Subsets, Fates, and Functions

Alexander Mildner, Goran Marinkovic, and Steffen Jung

10 Dendritic Cells in the Immune System History, Lineages, Tissues, Tolerance, and Immunity

Jonathan M. Austyn

11 Antigen Processing and Presentation Mechanisms in Myeloid Cells

Paul A. Roche and Peter Cresswell

12 Microglia

V. Hugh Perry

13 Osteoclasts Key Players in Skeletal Health and Disease

Deborah Veis Novack and Gabriel Mbalaviele

14 The Regulatory Function of Eosinophils

Ting Wen and Marc E. Rothenberg

SECTION IV RECRUITMENT, INFLAMMATION, AND REPAIR

15 Intravital Imaging of Myeloid Cells: Inflammatory Migration and Resident Patrolling

Justin F. Deniset and Paul Kubes

16 Multifaceted Functions of NOD-Like Receptor Proteins in Myeloid Cells at the Intersection of Innate and Adaptive Immunity

Thomas A. Kufer, Giulia Nigro, and Philippe J. Sansonetti

17 Inflammasomes in Myeloid Cells: Warriors Within

Sushmita Jha and Jenny Pan-Yun Ting

18 Inflammation a Critical Appreciation of the Role of Myeloid Cells

Asif J. Iqbal, Edward A. Fisher, and David R. Greaves

19 Lipid Mediators in Inflammation

Melanie Bennett and Derek W. Gilroy

20 Macrophage Proresolving Mediators the When and Where

Jesmond Dalli and Charles Serhan

21 Myeloid Cells in Cutaneous Wound Repair

Jenna L. Cash and Paul Martin

SECTION V RECOGNITION, SIGNALING, AND GENE EXPRESSION

22 The Role and Function of Fc? Receptors on Myeloid Cells

Stylianos Bournazos, Taia T. Wang, and Jeffrey V. Ravetch

23 Complement Receptors in Myeloid Cell Adhesion and Phagocytosis

Michael L. Dustin

24 Toll-Like Receptor Signaling and Its Inducible Proteins

Takashi Satoh and Shizuo Akira

25 Lectin Receptors Expressed on Myeloid Cells

Gordon D. Brown and Paul R. Crocker

26 G Protein-Coupled Receptors in Macrophages

Hsi-Hsien Lin and Martin Stacey

27 Molecular Mechanisms of Phagosome Formation

Valentin Jaumouillé and Sergio Grinstein

28 Role of the Cytoskeleton in Myeloid Cell Function

Noah Fine, Samira Khaliq, Siavash Hassanpour, and Michael Glogauer

29 Coordinated Regulation of Signaling Pathways during Macrophage Activation

Toby Lawrence

30 Genome-Wide Approaches to Defining Macrophage Identity and Function

Gregory J. Fonseca, Jason S. Seidman, and Christopher K. Glass

31 Epigenetic Regulation of Myeloid Cells

Lionel B. Ivashkiv and Sung Ho Park

SECTION VI SECRETION AND DEFENSE

32 Secretion from Myeloid Cells: Secretory Lysosomes

Gillian M. Griffiths

33 The NADPH Oxidase and Microbial Killing by Neutrophils, With a Particular Emphasis on the Proposed Antimicrobial Role of Myeloperoxidase within the Phagocytic Vacuole

Adam P. Levine and Anthony W. Segal

34 Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells

Ryan G. Gaudet, Clinton J. Bradfield, and John D. MacMicking

35 Anti-TNF Therapy

Irina Udalova, Claudia Monaco, Jagdeep Nanchahal, and Marc Feldmann

36 Metalloproteinases: a Functional Pathway for Myeloid Cells

Jonathan Chou, Matilda F. Chan, and Zena Werb

SECTION VII IMMUNOREGULATION AND INFECTION

37 Interplay between Myeloid Cells and Humoral Innate Immunity

Sébastien Jaillon, Eduardo Bonavita, Cecilia Garlanda, and Alberto Mantovani

38 Adaptive Characteristics of Innate Immune Responses in Macrophages

Rob J. W. Arts and Mihai G. Netea

39 Intestinal Mononuclear Phagocytes in Health and Disease

Theodore J. Sanders, Ulf Yrlid, and Kevin J. Maloy

40 Strategies Used by Bacteria to Grow in Macrophages

Gabriel Mitchell, Chen Chen, and Daniel A. Portnoy

41 Mechanisms of Defense against Intracellular Pathogens Mediated by Human Macrophages

Barry R. Bloom and Robert L. Modlin

42 Myeloid Cells in Asthma

Bart N. Lambrecht, Emma Persson, and Hamida Hammad

43 Myeloid Cell Phenotypes in Susceptibility and Resistance to Helminth Parasite Infections

Rick M. Maizels and James P. Hewitson

44 Induction of Immunological Tolerance as a Therapeutic Procedure

Herman Waldmann, Duncan Howie, and Stephen Cobbold

SECTION VIII METABOLIC AND MALIGNANT DISEASE

45 Glutathione and Glutathione Transferase Omega 1 as Key Post-Translational Regulators in Macrophages

Mark M. Hughes, Anne F. McGettrick, and Luke A.J. O'Neill

46 Macrophages and Iron Metabolism

Tomas Ganz

47 Mechanisms of Myeloid Cell Modulation of Atherosclerosis

Filip K. Swirski, Matthias Nahrendorf, and Peter Libby

48 Macrophages in Endocrine Glands with Emphasis on Pancreatic Islets

Emil R. Unanue

59 Tumor-Induced Myeloid-Derived Suppressor Cells

Francesco De Sanctis, Vincenzo Bronte, and Stefano Ugel

50 Myeloid Cell Origins, Differentiation, and Clinical Implications

Kipp Weiskopf, Peter J. Schnorr, Wendy W. Pang, Mark P. Chao, Akanksha Chhabra, Jun Seita, Mingye Feng, and Irving L. Weissman

Index