Chapters in new edition are fully updated with information from the latest research findings
New edition includes chapters on nitrite and nitrate and age medicine, hypertension, and exercise performance
Evidence-based chapters with detailed citations
Comprehensive coverage of nitrate and nitrite and human health, from a basic understanding of the biochemistry, to environmental factors, to therapeutic applications
Each chapter begins with detailed key points summarizing the major topics
This fully revised and updated new edition provides a comprehensive look at nitrite and nitrate and their effect on human health and disease. The first section describes the biochemical analysis of nitrite and nitrate and its role in human physiology. The book then shifts to sources of human exposure of nitrite and nitrate, including environmental and dietary. Finally, the last section discusses nitric oxide-based therapeutics and how nitrite and nitrate biochemistry can be safely harnessed to improve human health. Each chapter provides a balanced, evidence-based view and heavily cites the most recent published literature. They follow a strict chapter format which includes keywords, key points, a conclusion highlighting major findings, and extensive references.
The second edition contains new chapters on nitrite and nitrate in age medicine, nitrite and nitrate as a treatment for hypertension, and nitrite and nitrate in exercise performance. Additionally, the editors have expanded the biochemistry section to include chapters on nitrate reducing oral bacteria, nitrite mediated S-Nitrosation, epigenetics and the regulation of nitric oxide, and nitrite control of mitochondrial function.
Nitrate and Nitrite in Human Health and Disease, 2e, will be of interest to health professionals, nutritionists, dieticians, biomedical scientists, and food scientists.

Table of contents (22 chapters)
Introduction
Bryan, Nathan S. (et al.)
Pages 3-10
From Atmospheric Nitrogen to Bioactive Nitrogen Oxides
Gilchrist, Mark (et al.)
Pages 11-19
Nitrate-Reducing Oral Bacteria: Linking Oral and Systemic Health
Bryan, Nathan S. (et al.)
Pages 21-31
Epigenetics and the Regulation of Nitric Oxide
Handy, Diane E. (et al.)
Pages 33-52
The Mitochondrion: A Physiological Target of Nitrite
Guimaraes, Danielle A. (et al.)
Pages 53-68
Sources of Exposure to Nitrogen Oxides
Milkowski, Andrew L.
Pages 69-82
History of Nitrite and Nitrate in Food
Keeton, Jimmy T.
Pages 85-97
Nutritional Epidemiology of Nitrogen Oxides: What Do the Numbers Mean?
Lajous, Martin (et al.)
Pages 99-109
Nutritional Impact on the Nitric Oxide Pathway
Wong, Wing Tak (et al.)
Pages 111-128
Dietary Flavonoids as Modulators of NO Bioavailability in Acute and Chronic Cardiovascular Diseases
Totzeck, Matthias (et al.)
Pages 129-140
Nitrite and Nitrate in Human Breast Milk: Implications for Development
Berens, Pamela D. (et al.)
Pages 141-152
Regulation of Dietary Nitrate and Nitrite: Balancing Essential Physiological Roles with Potential Health Risks
Hord, Norman G. (et al.)
Pages 153-162
Nitric Oxide Signaling in Health and Disease
Bryan, Nathan S. (et al.)
Pages 165-178
Inhaled Nitric Oxide
Bloch, Kenneth D. (et al.)
Pages 179-193
Pharmacology of Nitrovasodilators
Münzel, Thomas (et al.)
Pages 195-216
Nitrite and Nitrate in Ischemia Reperfusion Injury
Lefer, David J. (et al.)
Pages 217-234
Nitrite and Nitrate as a Treatment for Hypertension
Kapil, Vikas
Pages 235-258
Nitrate and Nitrite in Aging and Age-Related Disease
Johnson, Lawrence C. (et al.)
Pages 259-277
The Nitrate Nitrite Nitric Oxide Pathway in Traditional Herbal Medicine and Dietary Supplements with Potential Benefits for Cardiovascular Diseases
Geng, Yong-Jian
Pages 279-291
Nitrate and Exercise Performance
Bailey, Stephen J. (et al.)
Pages 293-310
Nitrite and Nitrate in Cancer
Klurfield, David M.
Pages 311-323
Looking Forward
Bryan, Nathan S. (et al.)
Pages 325-336