Comprehensively documents the most recent developments in experimental and clinical research in intensive care and emergency medicine
Written by acknowledged experts in the field
Broad appeal for all who work in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine

The Annual Update compiles the most recent developments in experimental and clinical research and practice in one comprehensive reference book. The chapters are written by well recognized experts in the field of intensive care and emergency medicine. It is addressed to everyone involved in internal medicine, anesthesia, surgery, pediatrics, intensive care and emergency medicine.

Table of contents (39 chapters)
Interpreting Procalcitonin at the Bedside
Fazakas, J. (et al.)
Pages 3-14
Reducing Antibiotic Use in the ICU: A Time-Based Approach to Rational Antimicrobial Use
Depuydt, P. O. (et al.)
Pages 15-23
Plasmacytoid Dendritic Cells in Severe Influenza Infection
Tang, B. M. (et al.)
Pages 25-33
Critically Ill Patients with Middle East Respiratory Syndrome Coronavirus Infection
Al-Dorzi, H. M. (et al.)
Pages 35-46
Immunomodulation: The Future for Sepsis?
Girardot, T. (et al.)
Pages 49-59
Norepinephrine in Septic Shock: Five Reasons to Initiate it Early
Jozwiak, M. (et al.)
Pages 61-68
Myths and Facts Regarding Lactate in Sepsis
Nalos, M. (et al.)
Pages 69-78
Creatinine-Based Definitions: From Baseline Creatinine to Serum Creatinine Adjustment in Intensive Care
De Rosa, S. (et al.)
Pages 81-89
Detrimental Cross-Talk Between Sepsis and Acute Kidney Injury: New Pathogenic Mechanisms, Early Biomarkers and Targeted Therapies
Dellepiane, S. (et al.)
Pages 91-109
Timing of Acute Renal Replacement Therapy
Jörres, A.
Pages 111-116
(Multiple) Organ Support Therapy Beyond AKI
Ricci, Z. (et al.)
Pages 117-129
Crystalloid Fluid Therapy
Reddy, S. (et al.)
Pages 133-148
Emergency Reversal Strategies for Anticoagulants and Antiplatelet Agents
Levi, M.
Pages 151-162
Bedside Myocardial Perfusion Assessment with Contrast Echocardiography
Orde, S. (et al.)
Pages 165-176
Pathophysiological Determinants of Cardiovascular Dysfunction in Septic Shock
Guarracino, F. (et al.)
Pages 177-184
Cardiovascular Response to ECMO
Akin, S. (et al.)
Pages 185-194
Mechanical Circulatory Support in the New Era: An Overview
Shekar, K. (et al.)
Pages 195-215
Cardiac Arrest in the Elderly: Epidemiology and Outcome
Sandroni, C. (et al.)
Pages 219-229
Regional Systems of Care: The Final Link in the Chain of Survival Concept for Out-of-Hospital Cardiac Arrest
Tagami, T. (et al.)
Pages 231-240
Cardiac Arrest Centers
Riley, E. L. (et al.)
Pages 241-254
High-Flow Nasal Cannula Oxygen Therapy: Physiological Effects and Clinical Data
Chiumello, D. (et al.)
Pages 257-270
The Potential Value of Monitoring the Oxygen Reserve Index in Patients Receiving Oxygen
Perel, A.
Pages 271-280
Variable Ventilation from Bench to Bedside
Huhle, R. (et al.)
Pages 281-298
Monitoring Respiratory Effort by Means of the Electrical Activity of the Diaphragm
Grasselli, G. (et al.)
Pages 299-310
Dissipated Energy is a Key Mediator of VILI: Rationale for Using Low Driving Pressures
Serpa Neto, A. (et al.)
Pages 311-321
Corticosteroids as Adjunctive Therapy in Severe Community-Acquired Pneumonia
Cillóniz, C. (et al.)
Pages 323-328
The Neglected Role of Abdominal Compliance in Organ-Organ Interactions
Malbrain, M. L. N. G. (et al.)
Pages 331-350
Metabonomics and Intensive Care
Antcliffe, D. (et al.)
Pages 353-363
The Rationale for Permissive Hyperglycemia in Critically Ill Patients with Diabetes
M rtensson, J. (et al.)
Pages 365-372
Indirect Calorimetry in Critically Ill Patients: Concept, Current Use, and Future Challenges
Waele, E. (et al.)
Pages 373-381
Managing Intensive Care Supply-Demand Imbalance
Leung, C. C. H. (et al.)
Pages 385-392
Advances in the Management of the Potential Organ Donor After Neurologic Determination of Death
Confalonieri, A. (et al.)
Pages 393-403
Humanizing Intensive Care: Theory, Evidence, and Possibilities
Brown, S. M. (et al.)
Pages 405-420
Ultrasound Simulation Education for Intensive Care and Emergency Medicine
Clau-Terré, F. (et al.)
Pages 423-434
Virtual Patients and Virtual Cohorts: A New Way to Think About the Design and Implementation of Personalized ICU Treatments
Chase, J. G. (et al.)
Pages 435-448
Predicting Cardiorespiratory Instability
Pinsky, M. R. (et al.)
Pages 451-464
Long-Term Outcomes After Critical Illness Relevant to Randomized Clinical Trials
Hodgson, C. L. (et al.)
Pages 465-474
Long-Term Consequences of Acute Inflammation in the Surgical Patient: New Findings and Perspectives
Forget, P.
Pages 475-482
Kairotropy: Discovering Critical Illness Trajectories Using Clinical Phenotypes with Big Data
Weissman, G. E. (et al.)