Review on the hypotheses about how acute leukemia in children is originated
A book to contribute to a greater understanding of the etiology of childhood acute leukemia
A guide for present and future approaches, contributing for a better clinical management of leukemia in children

Childhood acute leukemias are one of the main causes of death in children aged 1 to 14 years in some countries; and unfortunately, we have been unable to prevent it. Certainly, a good parcel of it is due to the poor understanding about its etiology. This book aims to describe the most important theories and hypothesis regarding childhood acute leukemia. Written by the most outstanding researchers in the field, this book intends to contribute to a greater understanding of the etiology of this disease. It goes beyond the simple and common analysis of risk factors, which hardly allows us to draw definite conclusions. By addressing the etiology of the disease, discussing from molecular biology until epidemiology and clinical manifestations, this book will guide present and future approaches, contributing for a better clinical management of leukemia in children. The knowledge regarding etiology is a crucial step for a better evaluation, prevention and treatment of a disease. Thus, this book finally intends to provide such knowledge, allowing physicians and practitioners to a better manage of childhood acute leukemias

Table of contents (9 chapters)
Introduction: Childhood Leukemia
Medina-Sanson, Aurora
Pages 1-48
Etiology and Prevention of Acute Leukemias in Children
Núñez-Enríquez, Juan Carlos (et al.)
Pages 49-74
HTLV-1 as a Model for Identifying the Causes of Human Leukemia
Arellano-Galindo, José (et al.)
Pages 75-88
Etiology of Leukemia in Children with Down Syndrome
Xavier, Ana C. (et al.)
Pages 89-108
Origin of Leukemia in Children with Down Syndrome
Hitzler, Johann K.
Pages 109-131
Model for the Origin of Acute Leukemias in Children: Interaction of Three Factors Susceptibility, Exposure, and Window of Vulnerability
Mejía-Aranguré, Juan Manuel
Pages 133-155
Molecular Origin of Childhood Acute Lymphoblastic Leukemia
Waanders, Esmé (et al.)
Pages 157-206
Environmental Factors and Exposure Time Windows Related to the Etiology of Acute Lymphoblastic Leukemia in Children
Pérez-Saldivar, Maria Luisa (et al.)
Pages 207-290
Early Hematopoietic Differentiation in Acute Lymphoblastic Leukemia: The Interplay Between Leukemia-Initiating Cells and Abnormal Bone Marrow Microenvironment
Vilchis-Ordoñez, Armando (et al.)
Pages 291-318