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The Retinoids: Biology, Biochemistry, and Disease provides an overview and synthesis of the retinoid molecules, from basic biology to mechanisms of diseases and therapy. Divided into five sections, the book covers retinoic acid signaling from biochemical, genetic, developmental, and clinical perspectives.

The text is divided into five sections, the first of which examines vitamin A metabolic and enzymatic pathways. Focus then shifts to the role of retinoic acid signaling in development, and then to retinoids and physiological function. The book concludes with chapters on retinoids, disease and therapy.

Comprehensive in scope and written by leading researchers in the field, The Retinoids: Biology, Biochemistry, and Disease will be an essential reference for biologists, biochemists, geneticists and developmental biologists, as well as for clinicians and pharmacists engaged in clinical research involving retinoids.

CONTENTS:
Part I: VITAMIN A METABOLIC AND ENZYMATE PATHWAYS
1. Vitamin a Metabolism, Storage and Tissue Delivery Mechanisms
2. Assimilation and Conversion of Dietary Vitamin a into Bioactive Retinoids
3. Intracellular Storage and Metabolic Activation of Retinoids: Lipid Droplets
4. Evolution of the Retinoic Acid Signaling Pathway

Part II: BIOCHEMISTRY AND CELLULAR BIOLOGY OF RETINOIC ACID SIGNALING
5. Control of Gene Expression by Nuclear Retinoic Acid Receptors: Post-Translational And Epigenetic Regulatory Mechanisms
6. Retinoic Acid Receptor Coregulators in Epigenetic Regulation of Target Genes
7. Retinoid Receptors: Protein Structure, Dna Recognition and Structure-Function Relationships
8. How the RAR-RXR Heterodimer Recognizes the Genome
9. Retinoid Receptor-Selective Modulators: Chemistry, 3D Structures and Systems Biology
10. Use of Retinoid Receptor Ligands to Identify Other Nuclear Receptor Ligands: Retinoid-Related Molecules are Ligands for the Small Heterodimer Partner (SHP) "Orphan" Receptor
11. The Dual Transcriptional Activity of Retinoic Acid
12. Retinoids, epigenetic changes during stem cell differentiation, and cell lineage choice

Part III: RETINOIC ACID SIGNALING IN DEVELOPMENT
13. Retinoic Acid Signaling and Central Nervous System Development
14. The Role of Retinoic Acid in Limb Development
15. Retinoic Acid Signaling and Heart Development
16. Retinoic Acid in the Developing Lung and Other Foregut Derivatives
17. Retinoic Acid and the Control of Meiotic Initiation

Part IV: RETINOIDS AND PHYSIOLOGICAL FUNCTIONS
18. Retinoids and the Visual Cycle: New Actors for an "OLD" Function
19. Retinoid Signaling in the Central Nervous System
20. Retinoid Turnover and Catabolism: Influences of Diet and Inflammation
21. Retinoids and the Immune System
22. Retinoic Acid Receptor Signaling in Post-Natal Male Germ Cell Differentiation

Part V: RETINOIDS, DISEASE AND THERAPY
23. Epidemiology and Prevention of Vitamin a Deficiency Disorders
24. Retinoid Pathway Gene Mutations and the Pathophysiology Of Related Visual Diseases
25. Retinoic Acid in Acute Myeloid Leukemias
26. Advances in the Use of Retinoids in Cancer Therapy and Prevention
Stock
NO
Idioma
Inglés
Nivel
Profesional
Formato
Encuadernado
Tapa Dura
Páginas
608
Largo
-
Ancho
-
Peso
-
Edición
Fecha de edición
12-06-2015
Año de edición
2015
Nº de ediciones
1
Colección
-
Nº de colección
-