Written by the leading names in pediatric oncology and hematology, Nathan and Oski's Hematology and Oncology of Infancy and Childhood offers you the essential tools you need to overcome the unique challenges and complexities of childhood cancers and hematologic disorders. Meticulously updated, this exciting full-color, two-volume set brings together the pathophysiology of disease with detailed clinical guidance to provide you with the most comprehensive, authoritative, up-to-date information for diagnosing and treating children.

TABLE OF CONTENTS

Section 1 Neonatal Hematology

1. Anatomy and Physiology of Hematopoiesis

2. The Neonatal Erythrocyte and Its Disorders

3. Neonatal Immune Hemolytic Disease

4. Disorders of Bilirubin Metabolism

5. Hemostasis in the Newborn and Infant

Section 2 Bone Marrow Failure

6. Acquired Aplastic Anemia and Pure Red Cell Aplasia

7. Inherited Bone Marrow Failure Syndromes

8. Principles of Bone Marrow and Stem Cell Transplantation

Section 3 Disorders of Erythrocyte Production

9. A Diagnostic Approach to the Anemic Patient

10. Megaloblastic Anemia

11. Disorders of Iron, Lead and Copper Metabolism and Sideroblastic Anemias

12. The Porphyrias

Section 4 Hemolytic Anemias

13. Autoimmune Hemolytic Anemia

14. Paroxysmal Nocturnal Hemoglobinuria and Other Nonimmune Acquired Anemias

15. The Red Cell Membrane

16. Disorders of the Red Cell Membrane

17. Pyruvate Kinase Deficiency and Disorders of Glycolysis

18. Glucose-6-Phosphate Dehydrogenase Deficiency

19. Hemoglobins: Normal and Abnormal

Section 5 Disorders of Hemoglobin

20. Sickle Cell Disease

21. The Thalassemias

Section 6 The Phagocyte System

22. The Phagocyte System and Disorders of Granulopoiesis and Granulocyte Function

Section 7 The Immune System

23. The Immune Response

24. Primary Immunodeficiency Diseases

Section 8 Storage Diseases

25. Storage Diseases of the Reticuloendothelial System

Section 9 Hemostasis

26. Platelets and the Vessel Wall

27. Blood Coagulation

28. The Molecular Basis of Fibrinolysis

29. Clinical and Laboratory Approach to the Patient with Bleeding

30. Inherited Platelet Disorders

31. Hemophilia and von Willebrand Disease

32. Rare Hereditary Coagulation Factor Abnormalities

33. Inherited Disorders of Thrombosis and Fibrinolysis

34. Acquired Platelet Defects

35. Acquired Disorders of Hemostasis

Section 10 Supportive Therapy

36. Transfusion Medicine

Section 11 Hematologic Manifestations of Systemic Diseases

37. Hematological Manifestations of Systemic Diseases

38. Hematology in the Developing World

Section 12 Biology of Cancer

39. Origins and Evolution of Pediatric Cancer

40. Epidemiology of Leukemia in Childhood

41. Childhood Genetic Predisposition Syndromes

42. Epigenetics and Genetics of Childhood Cancers

43. Targeted Therapies in Oncology

44. Cytogenetic and Molecular Pathology of Pediatric Cancer

Section 13 Pediatric Cancer Therapeutics

45. Chemotherapy in the Pediatric Cancer Patient

46. Immunotherapy of Cancer

47. Pediatric Radiation Oncology

48. Pediatric Surgical Oncology

Section 14 Hematologic Malignancy

49. Acute Lymphoblastic Leukemia

50. Pediatric Myeloid Leukemia, Myelodysplasia, and Myeloproliferative Disease

51. Infant Leukemias

52. Malignant Lymphomas and Lymphadenopathies

Section 15 Solid Tumors

53. Neuroblastoma

54. Pediatric Renal Tumors

55. Retinoblastoma

56. Tumors of the Brain and Spinal Cord

57. Hepatoblastomas and Other Liver Tumors

58. Rhabdomyosarcoma

59. Nonrhabodmyosarcomas and Other Soft Tissue Tumors

60. Ewing's Sarcoma

61. Osteosarcoma

62. Pediatric Germ Cell Tumors

63. Histocytoses

64. Rare Tumors of Childhood

65. Diagnostic Imaging in the Evaluation of Childhood Cancer

Section 16 Supportive Care

66. Infectious Disease in the Pediatric Cancer Patient

67. Oncologic Emergencies

68. Nursing Care of Patients with Childhood Cancer

69. Palliative Care in Pediatric Oncology

70. Symptom Management in Children with Cancer

71. Childhood Cancer Survivorship

72. Psychosocial Care of Children and Families

73. Ethical Considerations in Pediatric Oncology Clinical Trials

Appendices

Reference Values in Infancy and Childhood