Through the integration of strategies from life science, engineering, and clinical medicine, tissue engineering and regenerative medicine hold the promise of new solutions to current health challenges. This rapidly developing field requires continual updates to the state-of-the-art knowledge in all of the aforementioned sciences. Tissue Engineering and Regenerative Medicine: A Nano Approach provides a compilation of the important aspects of tissue engineering and regenerative medicine, including dentistry, from fundamental principles to current advances and future trends.

Written by internationally renowned scientists, engineers, and clinicians, the chapters cover the following areas:

Nanobiomaterials and scaffolds including nanocomposites and electrospun nanofibers
Tissue mechanics
Stem cells and nanobiomaterials
Oral and cranial implants and regeneration of bone
Cartilage tissue engineering
Controlled release DNA, RNA, and protein delivery
Animal science and clinical medicine
The editors designed this textbook with a distinctive theme focusing on the utilization of nanotechnology, biomaterials science in tissue engineering, and regenerative medicine with the inclusion of important clinical aspects. In addition to injured veterans and other individuals, increased life expectancy in the industrialized world is creating a growing population that will require regenerative medicine, producing greater pressure to develop procedures and treatments to improve quality of life. This book bridges the gap between nanotechnology and tissue engineering and regenerative medicine, facilitating the merger of these two fields and the important transition from laboratory discoveries to clinical applications


Biostable Composite Biomaterials in Medical Applications
Pekka K. Vallittu

Bioceramic and Biopolymer Nanocomposite Materials for Use in Orthopedic Applications
Clark E. Barrett, Ruth E. Cameron, and Serena M. Best
Tailoring of Bioactive Glasses
Leena Hupa
Bioactive Ceramic Coatings for Metallic Implants
Niko Moritz, Paula Linderbäck, and Timo O. Närhi


Induction of Bone Formation by Calcium Phosphate-Based Biomimetic Macroporous Constructs
Ugo Ripamonti


Bioinspired Titanium Implants: The Concavity The Shape of Life
Ugo Ripamonti, Louise Renton, and Jean-Claude Petit

Bioactive Surface Modifications for Dental and Orthopedic Implants
Ivan Donati, Eleonora Marsich, Andrea Travan, and Sergio Paoletti
Oral Implants: Biological Background and Current Concepts in Peri-Implantitis Treatment
Nicola U. Zitzmann and Tuomas Waltimo


Soft Tissue Attachment on Implant Surface
Timo O. Närhi


Surface Chemical Determination of the Placement, Growth, and Differentiation of Cells for Drug Screening, Toxin Detection, and Lab-on-a- Chip Applications
Peter Molnar, Murugan Ramalingam, and James J. Hickman


Electrospun Nanofibers as Next-Generation Bioactive Tissue Scaffolds
Victor Leung, Ryan Hartwell, Elodie Faure, Heejae Yang,Aziz Ghahary, and Frank Ko


Mechanics of Fiber-Reinforced Scaffolds and Tissues Formed from Organized Electrospun Assemblies
Matthew B. Fisher and Robert L. Mauck


Regulation of Stem Cell Behavior Using Nanobiomaterials
Andrew M. Handorf, Patrick T. Brown, John G. Barber, andWan-Ju Li


Biomaterials and Their Use in Craniofacial Surgery
Kurt Laedrach


Nanobiomaterials for Bone Tissue Engineering
Meng Deng, Roshan James, Cato T. Laurencin, andSangamesh G. Kumbar
Stem Cells, Growth Factors, and Biomaterials in Bone Surgery
George K. B. Sándor
Nanomaterials for Cartilage Regeneration
Shirley Keolebogile Motaung and A. Hari Reddi


Cartilage Tissue Engineering: Advances in Stem Cell-Based Approaches
Sibylle Grad, Martin J. Stoddart, David Eglin, and Mauro Alini

Stem Cells and Nanobiomaterials for Cardiac Tissue Regeneration
Debasish Mondal
Nanotechnology for Engineering Cellular Microenvironment and Gene Delivery
Janice H. Lai, Anusuya Ramasubramanian,Shaheen Jeeawoody, and Fan Yang


Nanobiomaterial-Based Short Interfering RNA Delivery Systems
Yoon N. Cho, Murugan Ramalingam, and Ziyad S. Haidar


Sugar Glass Nanoparticles for Protein Delivery
Jyotsnendu Giri and Marcus T. Cicerone
Clinical Relevance of Tissue Engineering
Koteshwar N. Sridhar and Daniel G. Miller


Future Perspectives of Biomaterials and Stem Cells in Regenerative Medicine
Dilip Dey


Index