Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, reviews new, valuable approaches to the treatment of prostate cancer in men. The latest edition contains new material on molecular imaging, new treatments for prostate cancer, molecular targets, cell signaling pathways, bioinformatics, and pathogenomics. The book details the latest innovations and advances in prostate cancer and may be used as a rapid reference text for readers.

The volume profiles the latest advances in cancer research and treatment and includes profound studies in prostate stem cells, cancer-host interactions, hedgehog signaling in development and cancer, cholesterol and cell signaling, gene therapy for advanced prostate cancer, and noninvasive strategies such as molecular imaging to visualize gene expression. This new edition also investigates expression profiling and somatic alterations in prostate cancer progression and linkage studies of prostate cancer families to identify susceptibility genes. The issues of racial differences in prostate cancer mortality, radiotherapy for the treatment of locally advanced prostate cancer, recombinant antibody candidates for treatment, taxane-based chemotherapy, lethal phenotypes, and novel and efficient translation clinical trials are also presented in great depth.

Prostate Cancer: Biology, Genetics, and the New Therapeutics, Second Edition, provides readers with a general reference for prostate cancer from prevention to therapy and will be of value to clinicians, scientists, and administrators who strive to solve the cancer problem.

Table of contents
Prostate Cancer: Novel Biology, Genetics and Therapy

Part I Preface - to be submitted

The Lance Armstrong Effect: Turning up the Heat to Cure Other Advanced Cancers
Dr. Donald S. Coffey

Part II Biology and Imaging

1. Xenograft Models of Human Prostate Cancer
Drs. Robert Vessella and Eva Corey
2. The Pathology of Human Prostatic Atrophy and Inflammation
Dr. Angelo DeMarzo
3. Tissue Microarrays in Prostate Cancer Research
Drs. Milton Datta and André A. Kajdacsy-Balla
4. Prostate (Cancer) Stem Cells
Dr. Jack Schalken
5. Cancer-host interactions: A paradigm shift brings new understanding and new opportunities
Dr. Leland W. K. Chung, Dr. Wen-Chin Huang, Dr. Shian-Ying Sung, Dr. Daqing Wu, Dr. Valerie Odero-Marah, and Dr. Haiyen E. Zhau
6. Androgen Receptor Function in Prostate Cancer Progression
Drs. Helmut Klocker, Iris E. Eder, Barbara Comuzzi, Georg Bartsch and Zoran Culig
7. Hedgehog Signaling in Development and Cancer
Dr. Wade Bushman
8. Cholesterol, Cell Signaling and Prostate Cancer
Drs. Mohini Lutchman, Keith R. Solomon, and Michael R. Freeman
9. Gene Therapy for Advanced Prostate Cancer
Juan Antonio Jiménez, Xiong Li, MD, PhD, Thomas A. Gardner, MD, and Chinghai Kao, PhD
10. Role of Transforming Growth Factor-b in Immunotherapy of Prostate Cancer
Drs. Chung Lee, Ali Shah, Victoria Liu, Irwin Park, Larry Wong, Xuemei Huang, Lijun Huang, Tim Fermin, Tom Jang, Som Kundu, Vivian Zhou, Qiang Zhang, Norm Smith
11. Biology and Therapeutic Basis of Prostate Cancer Bone Metastasis
Dr. Evan Keller
12. Molecular Imaging: Noninvasive Strategies to Visualize Gene Expression in Living Subjects
Drs. Meera Iyer and Sanjiv S. Gambhir
13. Quantum Dot Nanotechnology for Prostate Cancer Research
Drs. Xiaohu Gao, Yun Xing, Leland C. W. Chung, and Shuming Nie

Part III Genetics

14. Expression Profiling of Prostate Cancer Progression
Drs. Scott A. Tomlins, Arul M. Chinnaiyan
15. Somatic Alterations in Prostate Cancer Progression
Drs. Kati P. Porkka and Tapio Visakorpi
16. Linkage Studies of Prostate Cancer Families to Identify Susceptibility Genes
Drs. Bill Isaacs and Jianfeng Xu
17. Somatic DNA Methylation Changes and Prostatic Carcinogenesis
Drs. William G. Nelson, Srinivasan Yegnasubramanian, Patrick J. Bastian, Masashi Nakayama, and Angelo M. De Marzo
18. Telomeres, Telomerase, Chromosome Stability and Prostate Cancer
Dr. Alan Meeker

Part IV Therapeutics

19. Racial Differences in Prostate Cancer Mortality
Dr. James Mohler
20. Radiotherapy for the Treatment of Locally Advanced Prostate Cancer
Dr. Theodore DeWeese and Danny Song
21. Recombinant Antibody Candidates for Treatment of Prostate Cancer
Drs. Anoop M. Meraney and Warren W.D. Heston
22. Differentiation Agents and Epigenomics Therapies: An Overview and Potential Use for Prostate Cancer
Drs. Madeleine S. Q. Kortenhorst, Michael A. Carducci, Shabana Shabbeer
23. Taxane-based Chemotherapy for Prostate Cancer
Drs. Supriya G. Mohile and Daniel Petrylak
24. Co-Targeting Therapeutics for Hormone Refractory Prostate Cancer
Dr. Vassily Assikis
25. New Intercellular Targets Lethal Phenotypes of Prostate Cancer
Drs. Daniel George and Young E. Whang
26. Novel and Efficient Translational Clinical Trials Designs in Advanced Prostate Cancer
Drs. André Rogatko and Mourad Tighiouart